Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds
2013
Authors:
Radović, MilošŠiler, Branislav
Nestorović Živković, Jasmina
Banjanac, Tijana
Živković, Suzana
Nikolić, Miloš
Soković, Marina
Mišić, Danijela
Document Type:
Article (Published version)
,
© 2013 by ACG Publications
Metadata
Show full item recordAbstract:
With regard to world’s increasing demand for biologically active compounds, a novel source of xanthones and secoiridoid glycosides has been studied. Zeltnera beyrichii (Torr. & A. Gray) Mans., an
insufficiently acknowledged North American medicinal plant species, may be considered a pharmacological substitute for commercial C. erythraea Rafn, since it accumulates in aerial parts nearly the same amount of secoiridoid glycosides: swertiamarin, gentiopicrin, and sweroside (13.76, 7.56, and 0.17 mmol per 100 g dry weight, respectively) in plants grown under greenhouse condition, and a considerable amount of xanthones: decussatin and eustomin. Additionally, Z. beyrichii produced as much biomass during cultivation in RITA® temporary immersion bioreactors as greenhouse-grown plants, in a third of the time. Plants grown in bioreactors contained moderate levels of total phenolics and total flavonoids, and possessed modest antioxidant activity and antimicrobial potential against eight bacterial and eight fungal species. Therefore, this species may be highly recommended for cultivation either in natural environment, or in bioreactors under in vitro conditions, for producing compounds of interest of modern pharmacology and food industry.
Keywords:
Zelnera beyrichii; temporary immersion bioreactors; secoiridoid glycosides; xanthones; antioxidant activity; antimicrobial activitySource:
Records of Natural Products, 2013, 7, 4, 266-280Funding / projects:
- Physiological, chemical and molecular analysis of the diversity of selected rare and endangered plant species and application of biotechnology for ex situ conservation and production of biologically active compounds (RS-MESTD-Basic Research (BR or ON)-173024)
- Application of low temperature plasmas in biomedicine, environmental protection and nanotechnologies (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41011)
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-MESTD-Basic Research (BR or ON)-173032)