Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds
2013
Autori:
Radović, MilošŠiler, Branislav
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Nestorović Živković, Jasmina
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Banjanac, Tijana
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Živković, Suzana
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Nikolić, Miloš
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Soković, Marina
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Mišić, Danijela
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Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2013 by ACG Publications
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
With regard to world’s increasing demand for biologically active compounds, a novel source of xanthones and secoiridoid glycosides has been studied. Zeltnera beyrichii (Torr. & A. Gray) Mans., an
insufficiently acknowledged North American medicinal plant species, may be considered a pharmacological substitute for commercial C. erythraea Rafn, since it accumulates in aerial parts nearly the same amount of secoiridoid glycosides: swertiamarin, gentiopicrin, and sweroside (13.76, 7.56, and 0.17 mmol per 100 g dry weight, respectively) in plants grown under greenhouse condition, and a considerable amount of xanthones: decussatin and eustomin. Additionally, Z. beyrichii produced as much biomass during cultivation in RITA® temporary immersion bioreactors as greenhouse-grown plants, in a third of the time. Plants grown in bioreactors contained moderate levels of total phenolics and total flavonoids, and possessed modest antioxidant activity and antimicrobial potential against eight bacterial and eight fungal species. Therefore, this species may be highly recommended for cultivation either in natural environment, or in bioreactors under in vitro conditions, for producing compounds of interest of modern pharmacology and food industry.
Ključne reči:
Zelnera beyrichii; temporary immersion bioreactors; secoiridoid glycosides; xanthones; antioxidant activity; antimicrobial activityIzvor:
Records of Natural Products, 2013, 7, 4, 266-280Finansiranje / projekti:
- Fiziološka, hemijska i molekularna analiza diverziteta odabranih retkih i ugroženih biljnih vrsta u cilju ex situ zaštite i produkcije biološki aktivnih jedinjenja (RS-MESTD-Basic Research (BR or ON)-173024)
- Primene niskotemperaturnih plazmi u biomedicini, zaštiti čovekove okoline i nanotehnologijama (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41011)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)