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Sinteza i farmakološko ispitivanje novih derivata N-(2-nitrofenil) piperazina
Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives
dc.creator | Andrić, Deana | |
dc.creator | Tovilović-Kovačević, Gordana | |
dc.creator | Roglić, Goran | |
dc.creator | Ignjatović, Đurđica | |
dc.creator | Šoškić, Vukić | |
dc.creator | Tomić, Mirko | |
dc.creator | Kostić-Rajačić, Slađana V. | |
dc.date.accessioned | 2015-08-28T10:26:51Z | |
dc.date.available | 2015-08-28T10:26:51Z | |
dc.date.issued | 2007 | sr |
dc.identifier.issn | 0352-5139 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/553 | |
dc.description.abstract | Six newly synthesized heterocyclic (2-nitrophenyl)piperazines, with a specific structure of the heteroaryl group, whichmimics the catechol moiety of dopamine (benzimidazoles and substituted benzimidazoles), were evaluated for their binding affinity to rat dopamine (DA), serotonin (5-HT) and _1 receptors. All compounds with a benzimidazole group had a 5-HT2A/D2 receptors binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 7c, 4-bromo-6-{2-_4-(2-nitrophenyl)piperazin- 1-yl_ethyl}-1H-benzimidazole, expressed higher affinities for all receptor classes than clozapine. Also, it exhibited the best characteristic for atypical neuroleptics and presents a compound with the best profile for further in vivo investigations. | en |
dc.description.abstract | Sintetisano je šest heterocikličnih (2-nitrofenil)piperazina sa specifičnom heteroaril grupom, koja podražava kateholsku grupu dopamina (benzimidazoli i supstituisani benzimidazoli), i ispitan je njihov afinitet ka dopaminskim, serotoninskim i _1 receptorima. Sva jedinjenja sa benzimidazolskim grupama su pokazala 5-HT 1A/D2 odnos vezivanja karakterističan za atipične neuroleptike (>1, pK i vrednosti). Jedinjenje 7c, 4-bromo-6-{2-_4-(2-nitrofenil)piperazin-1-il_etil}-1H-benzimidazol, pokazalo je izraženiji afinitet ka svim klasama receptora u poređenju sa klozapinom i takođe predstavlja jedinjenje sa najboljim karakteristikama za dalja in vivo istraživanja. | sr |
dc.description.sponsorship | null | sr |
dc.language.iso | eng | sr |
dc.publisher | Belgrade: Serbian Chemical Society | |
dc.rights | openAccess | sr |
dc.source | Journal of the Serbian Chemical Society | sr |
dc.subject | arylpiperazines | ENG |
dc.subject | benzimidazoles | ENG |
dc.subject | dopamine receptors | ENG |
dc.subject | serotonin receptors | ENG |
dc.subject | atypical antipsychotic | ENG |
dc.title | Sinteza i farmakološko ispitivanje novih derivata N-(2-nitrofenil) piperazina | sr |
dc.title | Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives | en |
dc.type | article | sr |
dc.rights.license | ARR | |
dcterms.abstract | Роглић, Горан; Aндрић, Деана; Костић-Рајачић, Слађана В.; Товиловић, Гордана; Шошкић, Вукић; Васковић, Ђурђица; Томић, Мирко; Синтеза и фармаколошко испитивање нових деривата Н-(2-нитрофенил) пиперазина; Синтеза и фармаколошко испитивање нових деривата Н-(2-нитрофенил) пиперазина; | |
dc.rights.holder | @ 2007 by the Serbian Chemical Society | |
dc.citation.issue | 5 | sr |
dc.citation.volume | 72 | sr |
dc.identifier.doi | 10.2298/JSC0705429A | |
dc.identifier.scopus | 2-s2.0-34447136382 | |
dc.identifier.wos | 000247579900002 | |
dc.citation.spage | 429 | sr |
dc.citation.epage | 435 | sr |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/3029/Rad_konverzija_86.pdf | |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_553 |