Chemical constituents and biological activities of two Nepeta species: N. cataria L. and N. nuda L.
2022
Аутори:
Nestorović Živković, JasminaDmitrović, Slavica
Aničić, Neda
Gašić, Uroš
Milutinović, Milica
Skorić, Marijana
Božunović, Jelena
Petrović, Luka
Šiler, Branislav
Filipović, Biljana
Banjanac, Tijana
Matekalo, Dragana
Todorović, Miloš
Lukić, Tamara
Mišić, Danijela
Остала ауторства
Baebler, ŠpelaDermastia, Marina
Grebenc, Tine
Praprotnik, Eva
Razinger, Jaka
Urbanek Krajnc, Andreja
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2022 by the Slovenian Society of Plant Biology
Метаподаци
Приказ свих података о документуАпстракт:
Many Nepeta species (fam. Lamiace, subfam. Nepetoideae, tribe Nepetae) are well known for their
pharmacological properties and are widely used in folk medicine as diuretic, diaphoretic, anti-tussive, antispasmodic, anti-asthmatic, febrifuge and sedative agents, against gastrointestinal and respiratory
hyperactive disorders (Formisano et al., 2011). They also show biopesticide potential and display
behavioural effect on cats. Various biological activities of Nepeta species are closely related to their main
secondary metabolites, among which terpenes and phenolics predominate. Two herbaceous perennial
Nepeta species investigated within the present study are widely distributed in EuroAsia. N. cataria L. is
spreaded from Central Europe to the Iranian plateaus and in Central Asia, and N. nuda L. grows throughout
Europe and European part of Russia, the Crimea, in the Dnieper area and on Carpathians in Ukraine, as well
as in Siberia (Boikova and Grishkina, 2019).
Untargeted metabolomics approach adopting UHPLC/LTQ Orbitrap−MSn revealed iridoids and phenolic
acids as the major groups of compounds in methanol extracts of both N. cataria and N. nuda.
UHPLC/(±)HESI−MS2 profiling of major compounds from these groups of metabolites revealed that
rosmarinic acid was the major phenolic acid in both species, while from the group of iridoids, 1,5,9-
epideoxyloganic acid predominated. Methanol extract of N. cataria was rich in iridoid aglycone cis,transnepetalactone. Based on the bioautography assays, methanol extracts of N. cataria and N. nuda show
moderate α-amylase activity, and display significant antioxidative activity, which is primarily ascribed to
high content of rosmarinic acid.
Финансирање / пројекти:
- NEPETOME - Omics-guided disentangling of the iridoid diversity in the genus Nepeta L. for in planta metabolic engineering towards sustainable exploitation (RS-ScienceFundRS-Ideje-7749433)
У:
- Baebler Š, Dermastia M, Grebenc T, Praprotnik E, Razinger J, Urbanek KrajncA , editors. Book of abstracts: Plants in Changing Environment: International conference of the Slovenian Society of Plant Biology; 2022 Sep 15-16; Ljubljana, Slovenia. Ljubljana: Slovenian Society of Plant Biology; 2022. p. 61.