The association of 5' haptoglobin gene-flanking sequences with nuclear matrix proteins during the acute phase response

Abstract

Haptoglobin (Hp) is one of several plasma proteins ‚whose concentration increases aout three times during the acute phase response (1). Its gene activity is controlled primarily by the action of transcriptional mechanisms (6). In the work we studied the changes in the binding potential of the rat Hp gene sequences in the vicinity of its cis-element (-165/-147) (4) to nuclear matrix proteins during acute inflammation induced by turpentine.