Antimicrobial Activity of Some Steroidal Hydrazones
2023
Authors:
Merlani, MaiaNadaraia, Nanuli
Amiranashvili, Lela
Petrou, Anthi
Geronikaki, Athina
Ćirić, Ana
Glamočlija, Jasmina
Carević, Tamara
Soković, Marina
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Twelve steroid based hydrazones were in silico evaluated using computer program PASS as antimicrobial agents. The experimental evaluation revealed that all compounds have low to moderate antibacterial activity against all bacteria tested, except for B.cereus with MIC at a range of 0.37–3.00 mg/mL and MBC at 0.75–6.00 mg/mL. The most potent appeared to be compound 11 with MIC/MBC of0.75/1.5 mg/mL, respectively. The evaluation of antibacterial activity against three resistant strains MRSA, E.coli and P.aeruginosa demonstrated superior activity of compounds against MRSA compared with ampicillin, which did not show bacteriostatic or bactericidal activities. All compounds exhibited good antifungal activity with MIC of 0.37–1.50 mg/mL and MFC of 1.50–3.00 mg/mL, but with different sensitivity against fungi tested. According to docking studies, 14-alpha demethylase inhibition may be responsible for antifungal activity. Two compounds were evaluated for their antibiofilm activity. Finally, drug-likeness and docking prediction were performed.
Keywords:
antimicrobial activity; hydrazones; ketosteroidsSource:
Molecules, 2023, 28, 3, 1167-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/molecules28031167
ISSN: 1420-3049
PubMed: 36770834