Plant and mushroom extracts as potential intervening supplements in diabetes and diabetic complications
2019
Аутори:
Arambašić Jovanović, JelenaMihailović, Mirjana
Uskoković, Aleksandra
Dinić, Svetlana
Đorđević, Miloš
Grdović, Nevena
Đorđević, Marija
Tolić, Anja
Rajić, Jovana
Poznanović, Goran
Vidaković, Melita
Остала ауторства
Soković, MarinaТип документа:
Конференцијски прилог (Објављена верзија)
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© 2019 Institute for Biological Research "Siniša Stanković", University of Belgrade
Метаподаци
Приказ свих података о документуАпстракт:
Diabetes is a metabolic disorder characterized by impaired pancreatic insulin production and/or insufficient cell response to insulin and is characterized by chronic hyperglycemia which induces metabolic abnormalities in different cells and tissues. High intracellular glucose concentrations induce the overproduction of reactive oxygen species and activate the formation of advanced glycation end-products, the polyol pathway, the hexosamine pathway and the protein kinase C pathway, influencing gene expression and activity of different regulatory proteins. These changes lead to diabetic end-organ complications affecting vascular system, kidneys, eyes, peripheral nerves, liver and gastrointestinal system. Diabetes represents one example of a disease that has been treated according to the traditional medicine world-wide and as such represents a good model for investigation of beneficial effect of different plant and mushroom extracts and isolated compounds in the management of diabetes and diabetes-related complications. Plants and mushrooms extracts are the source of metabolites such as polyphenols, polysaccharides, terpenes, alkaloids and antibiotics with pronounced biological activities including antioxidant, antitumor, anti-inflammatory, antidiabetic, antimutagenic, anti-hepatotoxic and immunostimulant properties. We provided an overview of the beneficial effects of the examined extracts obtained from flowering plant
(Centaurium erythraea), sweet chestnut (Castanea sativa), edible mushroom (Lactarius deterrimus) and natural products containing p-glucans (from cereal grains) in the treatment of diabetes. Their antioxidant and antidiabetic properties in vitro and positive effects on different processes involved in the onset and progression of diabetes and its complications in vivo are presented and possible mechanisms that underlie these effects are suggested.
Финансирање / пројекти:
- Сигнални молекули у дијабетесу: идентификација потенцијалних биолошких маркера укључених у модификацију и интеграцију сигналних путева у циљу предикције и интервенције у дијабетесу (RS-MESTD-Basic Research (BR or ON)-173020)
У:
- Soković M, editor. Book of abstracts: The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery; 2019 Apr 11-13; Belgrade, Serbia. Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade; 2019. p. 40.