The role of macrophage migration inhibitory factor in the development of obesity and altered intestinal permeability
2017
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Authors:
Saksida, TamaraMićanović, Dragica
Koprivica, Ivan
Nikolić, Ivana
Vujičić, Milica
Stošić-Grujičić, Stanislava
Stojanović, Ivana D.
Contributors
Spasojević, IvanDocument Type:
Conference object (Published version)
,
© 2017 by the Serbian Biochemical Society
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Show full item recordAbstract:
Macrophage migration inhibitory factor (MIF) is a molecule expressed both by the immune
cells, like T, B lymphocytes and macrophages, and non-immune cells, like adipocytes,
hepatocytes and beta cells of pancreatic islets. It has actions in the innate and adaptive
immunity, such as a part in regulating the interleukin-17 expression and production, but also
in the development of chemically induced type 1 diabetes in mice. This paper summarizes our
results on the role of MIF in the development of obesity and type 2 diabetes, done in vitro on
beta cell models and murine pancreatic islets, as well as in vivo, when mice with MIF deletion
(MIF-KO) and their wild type (wt) counterparts were on a high fat diet. It is considered that
obesity can develop as a consequence of altered intestinal permeability, so potential leakage of
the intestinal barrier is investigated in the MIF-KO and wt mice. Also, the interplay between
MIF and regulatory T cells, as an important regulator of inflammation in the adipose tissue, is
explored at the level of visceral adipose tissue.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
In:
- Spasojević I, editor. Biochemistry of Control in Life and Technology: Serbian Biochemical Society Seventh Conference with International Participation. 2017 Nov 10; Belgrade, Serbia. Belgrade: Faculty of Chemistry; 2017. p. 101-7.