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The role of macrophage migration inhibitory factor in the development of obesity and altered intestinal permeability
dc.contributor | Spasojević, Ivan | |
dc.creator | Saksida, Tamara | |
dc.creator | Mićanović, Dragica | |
dc.creator | Koprivica, Ivan | |
dc.creator | Nikolić, Ivana | |
dc.creator | Vujičić, Milica | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Stojanović, Ivana D. | |
dc.date.accessioned | 2023-05-29T15:42:48Z | |
dc.date.available | 2023-05-29T15:42:48Z | |
dc.date.issued | 2017 | |
dc.identifier.isbn | 978-86-7220-091-1 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/5766 | |
dc.description.abstract | Macrophage migration inhibitory factor (MIF) is a molecule expressed both by the immune cells, like T, B lymphocytes and macrophages, and non-immune cells, like adipocytes, hepatocytes and beta cells of pancreatic islets. It has actions in the innate and adaptive immunity, such as a part in regulating the interleukin-17 expression and production, but also in the development of chemically induced type 1 diabetes in mice. This paper summarizes our results on the role of MIF in the development of obesity and type 2 diabetes, done in vitro on beta cell models and murine pancreatic islets, as well as in vivo, when mice with MIF deletion (MIF-KO) and their wild type (wt) counterparts were on a high fat diet. It is considered that obesity can develop as a consequence of altered intestinal permeability, so potential leakage of the intestinal barrier is investigated in the MIF-KO and wt mice. Also, the interplay between MIF and regulatory T cells, as an important regulator of inflammation in the adipose tissue, is explored at the level of visceral adipose tissue. | sr |
dc.language.iso | en | sr |
dc.publisher | Belgrade: Faculty of Chemistry | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | openAccess | sr |
dc.source | Biochemistry of Control in Life and Technology: Serbian Biochemical Society Seventh Conference with International Participation. 2017 Nov 10; Belgrade, Serbia | sr |
dc.title | The role of macrophage migration inhibitory factor in the development of obesity and altered intestinal permeability | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2017 by the Serbian Biochemical Society | sr |
dc.description.other | Spasojević I, editor. Biochemistry of Control in Life and Technology: Serbian Biochemical Society Seventh Conference with International Participation. 2017 Nov 10; Belgrade, Serbia. Belgrade: Faculty of Chemistry; 2017. p. 101-7. | sr |
dc.citation.spage | 101 | |
dc.citation.epage | 107 | |
dc.type.version | publishedVersion | sr |
dc.identifier.cobiss | 249132044 | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/13166/bitstream_13166.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_5766 |