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Chokeberry (Aronia melanocarpa) fruit extract modulates mouse immune response in vivo and in vitro
dc.contributor | Spasojević, Ivan | |
dc.creator | Mićanović, Dragica | |
dc.creator | Saksida, Tamara | |
dc.creator | Koprivica, Ivan | |
dc.creator | Vujičić, Milica | |
dc.creator | Despotović, Sanja | |
dc.creator | Šavikin, Katarina | |
dc.creator | Janković, Teodora | |
dc.creator | Stojanović, Ivana D. | |
dc.date.accessioned | 2023-05-30T12:53:25Z | |
dc.date.available | 2023-05-30T12:53:25Z | |
dc.date.issued | 2019 | |
dc.identifier.isbn | 978-86-7220-101-7 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/5777 | |
dc.description.abstract | Chokeberry (Aronia melanocarpa) is known for its strong anti-oxidant properties. Antiinflammatory, anti-hypertensive and anti-diabetogenic activities of orally consumed chokeberry extracts have also been reported. The effects of chokeberry extract on the immune response parameters have been only sporadically assessed. Therefore, the aim of our study was to investigate the effects of orally consumed chokeberry extract on the immune response in vivo and in vitro in healthy and in diabetic C57BL/6 mice, in which diabetes was induced by multiple low doses of streptozotocin (MLDS). Chokeberry extract administered to healthy mice (50 mg/kg body weight) exerted immunomodulatory effects as evidenced by decreased proportion of F4/80+ macrophages, CD11c+ dendritic cells, CD4+ T helper cells, CD8+ T cytotoxic lymphocytes and CD4+CD25- activated T lymphocytes within the gut-associated lymphoid tissue. Surprisingly, oral consumption of chokeberry extract in doses of either 200 mg/kg bw or 50 mg/kg bw in diabetic mice resulted in the increase of blood glucose levels. In an attempt to decipher the underlying mechanisms of chokeberry extract effects in the context of autoimmune/inflammatory disease, we have evaluated its effects in vitro on purified immune cells. Seemingly, the chokeberry extract exerted pro-inflammatory effects in vitro through the up-regulation of nitric oxide and IL-1β production in macrophages and dendritic cells, increased macrophage CD86-related activation and promotion of type 1 T helper cells (IFN-γ+) differentiation. In addition, an increased proportion of CD4+, CD8+ and B lymphocytes within the spleen was observed. Collectively, the obtained results imply that our particular chokeberry extract displays pro-inflammatory characteristics and that care should be taken when chokeberry is to be included in the human diet. | sr |
dc.language.iso | en | sr |
dc.publisher | Belgrade: Faculty of Chemistry | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | openAccess | sr |
dc.source | The 9th Conference of the Serbian Biochemical Society: Diversity in Biochemistry; 2019 Nov 14-16; Belgrade, Serbia. | sr |
dc.title | Chokeberry (Aronia melanocarpa) fruit extract modulates mouse immune response in vivo and in vitro | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2019 by the Serbian Biochemical Society | sr |
dc.description.other | Spasojević I, editor. The 9th Conference of the Serbian Biochemical Society: Diversity in Biochemistry; 2019 Nov 14-16; Belgrade, Serbia. Belgrade: Faculty of Chemistry; 2019. p. 96. | sr |
dc.citation.spage | 96 | |
dc.type.version | publishedVersion | sr |
dc.identifier.cobiss | 280713228 | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/13470/bitstream_13470.pdf | |
dc.citation.rank | M34 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_5777 |