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Aronia berries fruit water extract stimulates cells of the immune system in vitro and in vivo
dc.contributor | Saksida, Tamara | |
dc.contributor | Stanisavljević, Suzana | |
dc.contributor | Miljković, Đorđe | |
dc.creator | Mićanović, Dragica | |
dc.creator | Saksida, Tamara | |
dc.creator | Koprivica, Ivan | |
dc.creator | Vujičić, Milica | |
dc.creator | Despotović, Sanja | |
dc.creator | Šavikin, Katarina | |
dc.creator | Janković, Teodora | |
dc.creator | Stojanović, Ivana D. | |
dc.date.accessioned | 2023-06-02T09:02:06Z | |
dc.date.available | 2023-06-02T09:02:06Z | |
dc.date.issued | 2021 | |
dc.identifier.isbn | 978-86-80335-12-4 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/5783 | |
dc.description.abstract | Many plant extracts are well known for their anti-oxidant, anti-bacterial and antiinflammatory activities including Aronia berry-derived juices and powders. In comparison to other black berries, Aronia berries have a greater content of phenolic constituents such as procyanidins, anthocyanins and phenolic acids with antioxidative and anti-inflammatory properties. However, the effects of aronia berries extract on the immune response parameters have been only sporadically assessed. When administered orally to healthy C57BL/6 mice (50 mg/kg body weight), aronia extract exerted immunomodulatory effects as evidenced by decreased proportion of F4/80+ macrophages, CD11c+ dendritic cells, CD4+ T helper cells, CD8+ T cytotoxic lymphocytes and CD4+CD25- activated lymphocytes within the gut-associated lymphoid tissue. Surprisingly, oral consumption of chokeberry extract in doses of either 200 mg/kg bw or 50 mg/kg bw in mice with multiple low dose streptozotocin-induced type 1 diabetes resulted in the increase of blood glucose levels. Further, our study shows that this detrimental effect on type 1 diabetes pathogenesis may be a consequence of the pro-inflammatory nature of the extract. This is based on the evident stimulation of macrophages and dendritic cells by the extract through up-regulation of proinflammatory mediators such as nitric oxide, IL-12, IL-6 and TNF in vitro. Also, this extract augmented differentiation of IFN-γ-producing T helper 1 cells in vitro. Collectively, the obtained results imply that our particular aronia berries fruit extract displays pro-inflammatory characteristics and that care should be taken when these berries are to be included in the human diet. | sr |
dc.language.iso | en | sr |
dc.publisher | Belgrade: Institute for Biological Research "Siniša Stanković"– National Institute of Republic of Serbia, University of Belgrade | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | openAccess | sr |
dc.source | Immunology at the Confluence of Multidisciplinary Approaches: abstract book: 2019 Dec 6-8; Belgrade, Serbia | sr |
dc.title | Aronia berries fruit water extract stimulates cells of the immune system in vitro and in vivo | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2019 Institute for Biological Research "Siniša Stanković" – National Institute of Republic of Serbia, University of Belgrade | sr |
dc.description.other | Saksida T, Stanisavljević S, Miljković Đ, editors. Immunology at the Confluence of Multidisciplinary Approaches : abstract book: 2019 Dec 6-8; Belgrade, Serbia. Belgrade: Institute for Biological Research "Siniša Stanković", University of Belgrade; Immunological Society of Serbia; 2019. p. 130. | sr |
dc.citation.spage | 130 | |
dc.type.version | publishedVersion | sr |
dc.identifier.cobiss | 281009420 | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/13455/bitstream_13455.pdf | |
dc.citation.rank | M34 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_5783 |