Fish oil supplementation suppress neuritic dystrophy and Аβ pathology in parietal cortex of 5XFAD mice
2017
Аутори:
Jović, MilenaLončarević-Vasiljković, Nataša
Avramović, Vladimir
Brkić, Marjana
Milanović, Desanka
Kanazir, Selma
Остала ауторства
Brajušković, GoranĐorđević, Ana
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2017 University of Belgrade, Faculty of Biology
Метаподаци
Приказ свих података о документуАпстракт:
Introduction: Alzheimer's disease (AD) is the most prevalent neurodegenerative
disease in elderly. Defining feature of AD pathology is the formation of amyloid
plaques, structures that are composed of fibrillar Amyloid-β organized in a β-sheet
conformation. In AD pathology the clinical symptoms mirror the pathological
changes in the brain, where the neuronal loss and plaque pathology occur in the
memory related areas. The onset of neuritic dystrophy represents the initial phase of
neurodegeneration. It occurs in an early phase of pathology called latent phase,
which leaves time frame for potential treatments. So far, omega 3 fatty acids
(omega-3 FA), one of the main compounds of fish oil (FO), represent one of the most
promising treatment. Here we investigated influence of omega-3 FA
supplementation on number of plaques, Aβ load and neuritic dystrophy in parietal
cortex in 5XFAD mice.
Methods: Three-month old female 5xFAD mice received FO (100 μl/animal/day) via
oral gavage during a 3-week period. Number of plaques, total Aβ levels and neuritic
dystrophy were visualized by immunohistochemistry and quantification was done by
Image J software.
Results: Our results showed that 3 weeks of FO supplementation significantly
decreased number of plaques, total Aβ levels and neuritic dystrophy in the parietal
cortex of FO-supplemented 5xFAD animals as compared to non-supplemented
5xFAD animals.
Conclusion: Since fish oil supplementation proved to be able to stop neuritic
dystrophy in the parietal cortex of 5xFAD mice it may represent good approach for
long term treatment in AD prevention.
Кључне речи:
Alzheimer's disease; omega 3 fatty acids; 5xFAD mouseФинансирање / пројекти:
- Пластичност мозга током старења: утицај дијеталне рестрикције и анестезије (RS-MESTD-Basic Research (BR or ON)-173056)
У:
- Brajušković G, Đorđević A, editors. Book of Abstracts: 1st Congress of Molecular Biologists of Serbia: CoMBoS; 2017 Sep 20-21; Belgrade, Serbia. Belgrade: University of Belgrade, Faculty of Biology; 2017. p. 45.