Dietary restriction during puberty changes locomotor and vertical activity of adult female Wistar rats in an onset- and duration-dependent manner
2023
Аутори:
Simeunović, ValentinaTodorović, Smilja
Prvulović, Milica
Sokanović, Srđan
Jović, Milena
Vukojević, Anđela
Milanović, Desanka
Mladenović, Aleksandra
Остала ауторства
Kanazir, SelmaSavić, Danijela
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2023 by Serbian Neuroscience Society and associates
Метаподаци
Приказ свих података о документуАпстракт:
Dietary restriction (DR) is one of the most studied environmental factors, which has
been shown to prolong life and enhance health. However, the outcome of DR depends
on both the duration of DR as well as the age of the individual at the onset of food
restriction. A few studies have been conducted on the impacts of DR during puberty,
but mainly casting doubt on beneficial effects it has on the individual.
In this experiment we studied the effect of 30% DR (70% of ad libitum daily intake)
during puberty on locomotor and vertical activity of 6- and 18-month-old female
Wistar rats. We examined the effects of DR of different onsets and durations: first one
that lasted from 28th to 35th day of life (Early Diet, ED), second lasted from 35th to
42nd day of life (Late Diet, LD), and the one that lasted from 28th to 42nd day of life
(Combined Diet, CD). The Open Field Test was used for tracking locomotor and
vertical activity.
Our findings demonstrated that in 6-month-old females all three types of DR
increased locomotor and vertical movement. Although the impact of DR during
puberty is evident in adults, it is lost during aging, as older animals showed no
significant change in locomotor or vertical activity under any type of DR.
Кључне речи:
Dietary restriction; Puberty; AgeingФинансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
У:
- Kanazir S, Savić D, editors. Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. Belgrade : Serbian Neuroscience Society; 2023. p. 69.