GABAergic parvalbumin-expressing interneurons play a role in memory impairment in rat models of Parkinson's disease
2023
Аутори:
Radovanović, LjiljanaŠaponjić, Jasna
Petrović, Jelena
Остала ауторства
Kanazir, SelmaSavić, Danijela
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2023 by Serbian Neuroscience Society and associates
Метаподаци
Приказ свих података о документуАпстракт:
We investigated the role of hippocampal GABAergic parvalbumin-expressing (PV)
interneurons in spatial and hippocampus-dependent memory abilities in rat models of
Parkinson's disease (PD).
Experiments were performed in adult male Wistar rats, including physiological
controls (n=14) and toxin lesion-induced PD models: PD cholinopathy (n=10),
hemiparkinsonism (n=7), and hemiparkinsonism with PD cholinopathy (n=6).
Behavioral assessments and PV immunohistochemistry were performed 14 and 42
days after lesions. Spatial habituation test and novel object recognition test were used
to assess spatial and hippocampus-dependent short- and long-term recognition
memory.
All experimental groups had no motor impairments during the follow-up period
(X2
≥2.01, p≥0.07). Although hippocampal PV expression remained unchanged over
time in PD cholinopathy (z≥-1.91, p≥0.06), we evidenced impairments in spatial,
short- and long-term recognition memory, but only at day 42 (X2
≥0.38, p=0.83;
t=0.13, p=0.91). In the hemiparkinsonian rats, unchanged hippocampal PV expression
(z≥-1.52, p≥0.14) was followed by impairment in spatial memory (X2
≥2.87, p≥0.22),
but both recognition memories were intact over time (t≥3.16, p≤0.03). In the
hemiparkinsonian rats with PD cholinopathy, long-lasting impairment of spatial
memory (X2
≥0.72, p≥0.22) was followed by delayed short- and long-term impairment
of recognition memory (t=-0.24, p=0.82) along with hippocampal PV suppression
(z=-3.17, p=10-3), which was functionally coupled to impairment of recognition
memory (r=0.52, p=0.04).
Our results suggest that dopaminergic denervation plays an important role in
impairing spatial memory in the prodromal stage of PD, whereas cholinergic
denervation and hippocampal PV suppression impair short- and long-term memory in
a delayed manner in PD cholinopathy and hemiparkinsonism with PD cholinopathy.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
У:
- Kanazir S, Savić D, editors. Book of abstracts: 8th Congress of Serbian neuroscience society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. Belgrade : Serbian Neuroscience Society; 2023. p. 49.