Effect of ELF-MF (50 Hz, 0.5 mT) on psychomotor behavior of rats caused by acute administration of MK-801
2023
Authors:
Kesić, SrđanStojadinović, Gordana
Martać, Ljiljana
Sekulić, Slobodan
Petković, Branka
Contributors
Kanazir, SelmaSavić, Danijela
Document Type:
Conference object (Published version)
,
© 2023 by Serbian Neuroscience Society and associates
Metadata
Show full item recordAbstract:
MK-801 can mimic the cognitive, negative, psychotic, and physiological features of
schizophrenia, including increased hyperlocomotion and altered behavioral flexibility.
As N-methyl-D-aspartate (NMDA) receptor antagonist, it is widely used to test the
“glutamate hypofunction hypothesis of schizophrenia”. An extremely low-frequency
magnetic field (ELF-MF) can stimulate NMDA receptor activity, but its effect on
dysregulated glutamine transmission is unknown. Therefore, this study addresses the
effect of continuous exposure to ELF-MF (50 Hz, 0.5 mT) for 7 days on rat
psychomotor behavior induced by acute administration of MK-801 (0.25 mg/kg, i.p.).
During the experiment, adult male Wistar rats were placed near the on/off generator of
ELF-MF, injected with MK-801/saline immediately after 7-day sham/ELF-MF
exposure, and subjected to the open field test for 2 hours. Their behavior was analyzed
using the ANY-maze software and expressed as travel distance, time in movement,
and average speed while in motion in 30-min intervals. The results show that (1) acute
administration of 0.25 mg/kg MK-801 significantly increased travel distance and time
in movement from 60 to 120 min and average speed while in motion from 60 to 90
min compared with saline-injected animals; (2) 7-day exposure to ELF-MF had no
significant effect on the behavior of saline- and MK-801-injected animals compared
with the corresponding controls. Therefore, it can be concluded that this regime of
ELF-MF exposure does not affect the psychomotor behavior of rats caused by the
pharmacological modification of glutamine transmission with the applied MK-801
dose.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
In:
- Kanazir S, Savić D, editors. Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. Belgrade: Serbian Neuroscience Society; 2023. p. 50.