The impact of sex on behavioral deficits in APP knock-in mouse model of Alzheimer's disease
2023
Authors:
Milovanović, NikolaJovanović Macura, Irena
Tešić, Vesna
Pavković, Željko
Perović, Milka
Pešić, Vesna
Ćirić, Jelena
Contributors
Kanazir, SelmaSavić, Danijela
Document Type:
Conference object (Published version)
,
© 2023 by Serbian Neuroscience Society and associates
Metadata
Show full item recordAbstract:
Alzheimer’s disease (AD) is progressive age-associated brain disorder and the main
cause of dementia in the elderly worldwide. It is also well-established that the
prevalence and severity of AD is greater in women than in men, suggesting that sex is
a crucial variable in disease heterogeneity.
Sex-biased differences in behavioral parameters related to cognition and depressive like behavior were examined in novel, state-of-the-art mouse model of AD-like
amyloidosis, APPNL-G-F knock-in (KI) mice. Nonspatial and spatial memory were
assessed using novel object recognition (NOR) and relocation test (NOL),
respectively, while for depressive-like behavior tail-suspension test (TST) was used.
Male and female APPNL-G-F mice and their non-APPNL-G-F KI littermates (WT) were
tested at the age of 9 months.
Memory impairments were evident in both WT and APPNL-G-F females in comparison
to their male littermates. In NOL as a spatial variation of NOR, the discrimination
index was decreased, but not in NOR as such. Furthermore, the decrease in total active
immobility time in TST test was also detected in female WT and APPNL-G-F mice vs.
male mice suggesting more prominent depressive-like behavior as well. Examined
parameters had similar pattern in WT and APPNL-G-F mice of both sexes.
The results suggest prominent sex-biased differences in behavior of males and females
in this particular model and support its validity for further studies revealing the impact
of sex to behavioral deficits.
Keywords:
Alzheimer's disease; Sex differences; BehaviorFunding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
In:
- Kanazir S, Savić D, editors. Book of abstracts: 8th Congress of Serbian Neuroscience Society with international participation; 2023 May 31 - Jun 2; Belgrade, Serbia. Belgrade: Serbian Neuroscience Society; 2023. p. 110.