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dc.contributorIsaković, Anđelka
dc.creatorSavić, Danijela
dc.creatorOpačić, Miloš
dc.creatorBrkljačić, Jelena
dc.creatorRistić, Aleksandar
dc.creatorSokić, Dragoslav
dc.creatorBaščarević, Vladimir
dc.creatorRaičević, Savo
dc.creatorSavić, Slobodan
dc.creatorZorović, Maja
dc.creatorŽivin, Marko
dc.creatorŠelih, Vid Simon
dc.creatorSpasić, Snežana
dc.creatorSpasojević, Ivan
dc.date.accessioned2023-07-05T11:23:15Z
dc.date.available2023-07-05T11:23:15Z
dc.date.issued2019
dc.identifier.isbn978-86-917255-3-2
dc.identifier.urihttp://radar.ibiss.bg.ac.rs/handle/123456789/5882
dc.description.abstractMore and more studies are identifying the regulation of metal homeostasis as one of the key points of central nervous system’s well-being. Epilepsy is a particularly interesting neurological condition when viewed in terms of the correlation between the amount of metals and the development of a seizure. This lecture will present contribution of our group to the field of metal biology in epilepsy by mapping brain metals in sclerotic hippocampus resected from drug resistant mesial temporal lobe epilepsy (mTLE) patients as surgical therapeutic approach. Direct insight into this epileptogenic area, by two powerful techniques, optical emission and mass spectrometry, has led us to investigation of copper turnover. Namely, among the examined metals, we found the deficiency of copper in sclerotic hippocampus on two levels: (i) in whole structure (ii) and locally in the areas of neuronal loss, with significant correlation between copper concentration and neuron density. Furthermore, analysis of copper metalloproteins showed: (i) significant increase or decrease in levels of protein that is participating in copper transport into the cell (CTR1) depending on the degree of hippocampal neuronal loss; (ii) and lower activity of an enzyme in which copper is part of the active site, cytochrome c oxidase, in sclerotic hippocampi of patients compared to control tissue. In our further investigations it remained to be determined whether changes in copper concentrations and copper metalloproteins are causal to pathology of mTLE or they represent epiphenomenon.sr
dc.language.isoensr
dc.publisherBelgrade: Serbian Neuroscience Societysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//sr
dc.relationSlovenian Research Agency (ARRS), Project numbers P3-0171 and P1-0034.sr
dc.rightsopenAccesssr
dc.sourceBook of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbiasr
dc.titleThe importance of copper in pathology of mesial temporal lobe epilepsysr
dc.typeconferenceObjectsr
dc.rights.licenseARRsr
dc.rights.holder© 2019 by the Serbian Neuroscience Societysr
dc.description.otherIsaković A, editor. Book of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbia. Belgrade: Serbian Neuroscience Society; 2019. p. 46.sr
dc.citation.spage46
dc.type.versionpublishedVersionsr
dc.identifier.cobiss282222604
dc.identifier.fulltexthttps://radar.ibiss.bg.ac.rs/bitstream/id/13846/Abstract-book-FENS-2019-Belgrade.pdf
dc.citation.rankM32
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_ibiss_5882


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