Whole mitochondrial genome diversity in serbian population: phylogenetic and forensic aspects
2019
Аутори:
Kovačević-Grujičić, NatašaDavidović, Slobodan
Malyarchuk, Boris
Grzybowski, Tomasz
Aleksić, Jelena
Derenko, Miroslava
Litvinov, Andrey
Rogalla-Ladniak, Urszula
Stevanović, Milena
Остала ауторства
Vasiljević, BrankaPatenković, Aleksandra
Nikolić Nađa
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2019 by the Serbian Genetic Society
Метаподаци
Приказ свих података о документуАпстракт:
Mitochondrial DNA (mtDNA) is used in forensics for over three decades and is particularly
suitable when STR profiling cannot be performed due to the degraded and/or scarce nuclear
DNA. Traditionally, mtDNA typing is based on ~600 bp of the hypervariable segments I and
II (HVS-I and HVS-II) of the control region (CR, ~1100 bp). Nowadays, it is possible to use
variability of complete mtDNAs which enables maximum resolution of distinct maternal
lineages. However, the number of complete mitogenomes in reference databases such as
EMPOP is still insufficient, and that hampers their wider usage in forensic casework. In order
to fill in the gap in the reference database, which, considering Slavic-speaking populations,
currently comprises only mitogenomes of East and West Slavs, we present population data
for 226 Serbian mitogenomes, representatives of South Slavs from the Balkan Peninsula. We
support previous findings on both high levels of genetic diversity in the Serbian population
and patterns of genetic differentiation among Serbian and ten studied European populations.
However, increased genetic differentiation was observed among Serbian and two European
populations (Russians and Poles) with our high resolution data. We demonstrate that
the inclusion of indel polymorphisms into analysis contributed towards nearly complete
resolution of mtDNA haplotypes (97.1% vs. 86.3% without indels), and that the random
match probability was as low as 0.53%. Bayesian skyline analysis of Serbian mitogenomes
revealed population expansion after the Last Glacial Maximum and during the Migration
period (IV-IX century A.D.). Phylogenetic analysis of the Serbian and relevant West Eurasian
haplotypes contributed towards the improvement of the worldwide mtDNA phylogeny to
the certain extent, which is essential for the interpretation of the mtDNA casework. Lineages
of a putative Balkan origin as well as those shared among Serbian and other European
populations were observed.
Кључне речи:
complete mitogenomes; demographic changes; molecular phylogeography; Serbian populationФинансирање / пројекти:
- Russian Foundation for Basic Research (grant numbers 14-04-00131 and 16-34-00014)
- Етногенеза Срба у средњем веку: Упоредна анализа историјско-културног наслеђа, генетичког материјала и предмета материјалне културе са аспекта аналитичке хемије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-47025)
У:
- Vasiljević B, Patenković A, Nikolić N, editors. 6th Congress of the Serbian genetic society: Book of abstracts; 2019 Oct 13-17; Vrnjačka Banja, Serbia. Belgrade: Serbian Genetic Society; 2019. p. 157.