Sinteza i citotoksičnost novih derivata sklareola
Synthesis and cytotoxic activity of novel sclareol derivatives
2023
Authors:
Stojković, Pavle A.Stepanović, Ana
Lupšić, Ema
Terzić Jovanović, Nataša
Novaković, Miroslav
Pešić, Milica
Opsenica, Igor M.
Contributors
Šojić Merkulov, DanielaDocument Type:
Conference object (Published version)
,
© 2023 by the Serbian Chemical Society
Metadata
Show full item recordAbstract:
Sclareol, a biologically active diterpenoid, was used as the starting material for the synthesis of novel hybrid molecules containing the 1,2,4-triazolo[1,5-a]-pyrimidine moiety. All sclareol derivatives were tested on human glioblastoma U87 and multi-drug resistant U87-TxR cells. Hybrid compounds decreased P-gp activity to the same extent as a third generation P-gp inhibitor - tariquidar. We examined the effect of novel compounds on various cellular processes including the cell cycle and cell death, as well as their influence on the levels of reactive oxygen and nitrogen species (ROS/RNS) and mitochondrial membrane potential in glioblastoma cells.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
In:
- Šojić Merkulov D, editor. Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia. Belgrade: Serbian Chemical Society; 2023. p. 77.