The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats

Abstract

Coenzyme Q10 in its reduced form (CoQ10Hz) is a powerful antioxidant. As an ant io x idant it is exploited either directly upon superoxide or indirectly on lipid radic als. CoQ:0H2 can also act together with Vitamin E by regenerating the active form from the tocopheroxyl radical. CoQ10 may prevent both the initiation and propagation of lipid peroxidation , prote cts DNA from oxidation causing by lipid peroxidation and protects organism from oxidative stre ss induced by various toxic agents. Cadmium (Cd) is a commonly occurring environmental contaminant which after being absorbed into the organism accumulates mostly in the liver and kidneys .