The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats
2002
Autori:
Ognjanović, BrankaPavlović, Slađan
Žikić, Radoslav V.
Štajn, Andraš Š.
Saičić, Zorica
Maletić, Snežana
Radojičić, Ratko
Petrović, Vojislav M.
Ostala autorstva
Littaru, Gian PaoloSchapira, Anthony
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
,
© 2002 by the International Coenzyme Q10 Association
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.
Ključne reči:
Kadmium; Rats; Coenzyme Q10; HeartFinansiranje / projekti:
- Serbian Ministry of Sciences, Yugoslavia, Grants No. 03E23 and 03E18.
U:
- Littaru GP, Schapira A, editors. Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom. International Coenzyme Q10 Association; 2002. p. 167-9.