Age related differences in glutathione metabolism in freshwater snail, Viviparus acerosus from the Danube river
2010
Аутори:
Despotović, SvetlanaGavrilović, Branka
Radovanović, Tijana
Gavrić, Jelena
Borković-Mitić, Slavica
Pavlović, Slađan
Paunović, Momir
Pajović, Snežana
Saičić, Zorica
Остала ауторства
Cvijić, GordanaAnđus, Pavle
Nedeljković, Nadežda
Radenović, Lidija
Đorđević, Jelena
Korać, Bato
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2010 University of Belgrade, Faculty of Biology
Метаподаци
Приказ свих података о документуАпстракт:
Data are presented in this study on the tissue glutathione (GSH) content and on the activity on the main enzymes involved in GSH metabolism ( glutathione peroxidase - GSH-Px, glutathione reductase - GR and phase II biotransfor mation enzyme glutathione-S-transferase - GST) in the whole body of fresh water snail, Viviparus acerosus of two different age groups - young and adults from the Danube River. The obtained results show, that there was no differences in content of GSH in both investigating groups of snails. We observed that the activity of GR was significantly lower in adults in comparison to young groups. The activity of GST was markedly higher in adults in respect to the young snails. Moreover, GSH-Px activity did not change in different age groups, this possible indicating no variation in organic peroxide production and/or metabolism during ageing process. Ageing seems to affect the activity of GSH related enzymes and, in particular, the activities of GR and phase II biotransformation enzyme GST. Our work represents the first study of its kind and these data indicate that, in age ing freshwater snails, Viviparus acerosus from the Danube river the increased susceptibility to oxidative stress is partly related in alteration in glutathione me tabolism.
Кључне речи:
Viviparus acerosus; Glutathione; Age; Danube riverФинансирање / пројекти:
- Проучавање поремећаја хомеостазе и одређивање биомаркера оксидационог стреса код аеробних организама (RS-MESTD-MPN2006-2010-143035)
У:
- Cvijić G, Anđus P, Nedeljković N, Radenović L, Đorđević J, Korać B, editors. Book of Abstracts: International Symposium One hunderd years of Ivan Djajać's (Jean Diaja) Belgrade School of Physiology; 2010 Sep 10-14; Belgrade, Serbia. Belgrade: University of Belgrade, Faculty of Biology; 2010. p. 97.