Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the role of selenium
2005
Аутори:
Ognjanović, BrankaMarković, Snežana
Pavlović, Slađan
Žikić, Radoslav V.
Štajn, Andraš Š.
Petrović, Vojislav M.
Saičić, Zorica
Остала ауторства
Đurić, DraganJakovljević, Vladimir
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2005 by the Serbian Physiology Society
Метаподаци
Приказ свих података о документуАпстракт:
Cadmium (Cd) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the tissues. Among antioxidant micronutrients, selenium (Se) is an essential dietary trace element which ·plays an important role in a number of biological processess. The effect of cadmium on the activity of glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) which play an important role in the detoxification of xenobiotics, was studied in the liver, kidney and heart of rats. Furthermore, the role of selenium in the modulation of Cd toxicity with respect to GSH-Px and GST was also evaluated. In our experiments, cadmium exposure (15 mg Cd/kg body wt./day as CdCh for 4 weeks) to rats (n=30, male Wistar rats, age 8 weeks) resulted in decreased GSH-Px and GST activity in all organs present in the order liver > kidney > heart. Oral administration of Se
(0.5 mg Se/kg body wt./day as Na2Se0 3 for 4 weeks) caused a significant increase in
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GSH-Px activity in the order liver> heart> kidney. Selenium administration caused d,
an increase in total GST activity in liver but a decrease in kidney and heart. Sf
Simultaneous administration of Cd and Se resulted in an increase GSH-Px and GST p,
activity in all tissues under study. Thus, the mechanism by which Se decreases Cd b,
toxicity in rats seems to rely on the protection of the enzyme systems GSH-Px and aJ GST in the three organs, possibly by forming non-toxic cadmium selenide. Selenium th efficiently protects tissues from cadmium-induced oxidative damage
Кључне речи:
Cadmium; Selenium; Antioxidant defense enzymes; RatsФинансирање / пројекти:
- Проучавање поремећаја хомеостазе и одређивање биомаркера оксидационог стреса код аеробних организама (RS-MESTD-MPN2006-2010-143035)
У:
- Đurić D, Jakovljević V, editors. Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia. Belgrade: Serbian Physiology Society; 2005. p. 202.