Effects of Coenzyme Q10 and Vitamin E on antioxidant defense system in the blood of rats acutely exposed to cadmium
2002
Аутори:
Ognjanović, BrankaPavlović, Slađan
Maletić, Snežana
Žikić, Radoslav V.
Štajn, Andraš Š.
Saičić, Zorica
Остала ауторства
Jablanović, MiodragТип документа:
Конференцијски прилог (Објављена верзија)
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© 2002 by the Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo
Метаподаци
Приказ свих података о документуАпстракт:
Cadmium induced lipid peroxidation (LPO) and altering the antioxidant system after the administration of a sin gle dose of CdCl2 (0.4 mg /kg body wt, i.p., 24 hours before the sacrificing) was studied in the blood of rats. The protect ive role of coenzyme Q (20 mg CoQ10/kg body wt, i.m., 48 hours before the sacrificing) and vita min E (20 iu Vit E/kg body wt, i. m., 48 hours before the sacrificing) was also studied in the blood of rats after the acute intoxication with cadmium. The treatment with Cd increased LPO in the blood while animals pre treated with coenzyme Q and/or vitamin E prior to Cd treatment showed decreased LPO as compared with animals given Cd alone. Activities of superoxide dismutase (SOD), catalase (CATt, glutathion e peroxidase (GS H-Px) and glut athione reductas e (GR) in erythrocytes and activities glutathione S-transferase (GST) as well as concentrations ascorbic acid (AsA) and vitamin E (Vit E) in the plasma were significantly incr eased of Cd and CoQ 10 treated rats (p<0.05 or Jess). The pre treatment with coen zyme Q and/or vitamin E prior to Cd administration partially reversed such changes. In animals treatment with antioxidants prior to Cd treatment decreased significantly activiti es of SOD, CAT and GR in erythrocytes, and activity GST and concentrations AsA in the plasma and were the same as con trols values. However, the pretreatment with coenzyme Q and/or vitamin E prior to Cd administration showed increased erythrocyte GSH-Px activity and concentrations vit amin E in the plasma as compared with animals given Cd alone. The results sugges that Cd int oxic ation induces oxidative stress and alters the antioxidant system, resulting in increased lipid peroxidation to rat erythrocytes. Coenzyme Q and vitamin E are the powerful liposoluble antioxidants which in cells quenched free oxygen radicals, inhibit lipid peroxidation and thus prevent free-radical mediated oxidant injuries. It is known that coenzyme Q and vitamin E may act sinergically as antioxidanrs. The pretreatment with coenzyme Q and /or vitamin E prior to Cd treatment showed protective effect against toxic influence of Cd on peroxidation of mem brane lipids and altering the antioxidant system in the blood of rats.
Кључне речи:
Coenzyme Q10; Vit E; Blood; Rats; Antioxidant defense system; CadmiumФинансирање / пројекти:
- Serbian Ministry of Sciences, Yugoslavia, Grants No. 03E23 and 03E18.
У:
- Jablanović M, editor. Conference of the Serbian Physiological Society; 2001 Dec 20-23; Zlatibor, Serbia. Priština: Academy of Sciences and Arts of SAP Kosovo. Division of Natural Sciences: Society for Biology and Experimental Medicine SAP Kosovo; 2002. p. 70. (Acta Biologiae et Medicinae Experimentalis; Vol. 27; No. 1; Suppl.).