Prevention of cadmium-induced effects on antioxidant defense system of rat heart by coenzyme Q10
2003
Аутори:
Ognjanović, BrankaPavlović, Slađan
Maletić, Snežana
Žikić, Radoslav V.
Štajn, Andraš Š.
Saičić, Zorica
Остала ауторства
Đurić, DraganТип документа:
Конференцијски прилог (Објављена верзија)
,
© 2003 by the Serbian Physiological Society
Метаподаци
Приказ свих података о документуАпстракт:
Cadmium (Cd) is a widely used industrial chemical and it is well known that Cd induces on oxidative stress that in oxidative deterioration of biological macromolec ules. Coenzyme Q10 (CoQ10) is a lipid co-factor th at is involved in numerous enzymatic processes and is present in most cellular membranes. Thus, CoQ1o is also important as a lipophilic regulator of oxidative stress.
The aim of this study was to investigate a possible protective influence of CoQ 10 in Cd induced oxidative stress in the rat hearts.
Male, Wistar albino rats (3 months old), injected with (I) CdCh (0.4 mg Cd/k b.m.,i.p., 24h before the sacrificing), (2) CoQ10 + Cd (20 mg CoQ10/kg b.m., i.m., 48 before the sacrificing + 0.4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and (3) CoQ10 (20 mg CoQ10/kg b.m., i.m., 48h before the sacri ficing). Acute intoxication· of rats with Cd were followed by significantly increased of all examined antioxidant
defense enzymes (total SOD, Mn SOD, CnZn SOD, CAT, GSH-Px, GST and GR), while AsA and Vit E concentrations were significantly decreased. A significantly increased accumulation of Cd in heart tissue was observed· in animals treated with Cd. These ubiquitous reaction·s of Cd result as its toxic effects on whole heart and other tissues and organs.
The protective role of CoQ1o in acute Cd intoxication results as decreased activities of total SOD, CuZn SOD, GSH-Px and GST. AsA concentration was also reversed to the control value. However, pretreatment with CoQ10 induced further increase of CAT and GR activities and Vit E concentration. Our results showed that CoQ10 functions as a lipid-soluble antioxidant, and protects cells from lipid peroxidation. The results of our study suggested that CoQ 10 functions as a potent antioxidant in protection of rat heart against oxidative stress induced by Cd.
Кључне речи:
Cadmium; Rats; Antioxidant defense system; HeartФинансирање / пројекти:
- Serbian Ministry of Sciences, Yugoslavia, Grants No. 03E23 and 03E18.
У:
- Đurić D, editor. Abstract Book: Conference of Physiological Sciences with international participation: Risk Factors and Health: from Molecule to the Scientific Basis of Prevention; 2003 Nov 7-9; Belgrade, Zrenjanin, Serbia. Belgrade: Serbian Physiology Society; 2003. p. 68.