Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.
2006
Аутори:
Pavlović, SlađanOgnjanović, Branka
Štajn, Andraš Š.
Žikić, Radoslav V.
Saičić, Zorica
Остала ауторства
Žikić, Radoslav V.Saičić, Zorica
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2006 by the Serbian Physiological Society
Метаподаци
Приказ свих података о документуАпстракт:
Cadmium (Cd) is a commonly occurring environmental contaminant which after being intake into the organism accumulates mostly in the liver and kidneys. Recent studies on mammals have shown that Cd stimulates formation of superoxide anion radicals, hydrogen peroxide and hydroxyl radicals. As a consequence, enhanced lipid peroxidation, DNA damage, altered calcium and sulfhydryl homeostasis, as well as marked disturbances of antioxidant defense system occur.
Coenzyme Q10 (CoQ10) in its reduced form (CoQ10H2) is a powerful antioxidant. As an antioxidant it is exploited either directly upon superoxide or indirectly on lipid radicals. CoQ10 may prevent both the initiation and propagation of lipid peroxidation, protects DNA from oxidation causing by lipid peroxidation and protects organism from oxidative stress induced by various toxic agents.
The activities of Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GR and phase II biotransformation enzyme-GST, as well as Vit C and Vit E concentrations were analyzed in the liver, heart and kidneys of male, two months old Wistar albino rats treated with Cd (200 mg CdCl2 x H2O, in drinking water during 30 days), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), concomitantly treated with Cd and CoQ10 (200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and in control animals (C).
This study suggested that Cd influences antioxidative defense enzyme activities in the liver, heart and kidneys of rats in various ways, especially depending on its metabolic activity. CoQ10 only partially (and tissue-specific) reversed Cd-induced changes on these enzymes. At the same time, CoQ10 exerts very strong beneficial effects on Vit C and Vit E by elevating its concentrations and thus induced an increase in antioxidative defense potential in investigated tissues of rats treated with Cd.
Кључне речи:
Cadmium; Coenzyme Q10; Antioxidant defense system; RatsФинансирање / пројекти:
- Проучавање поремећаја хомеостазе и одређивање биомаркера оксидационог стреса код аеробних организама (RS-MESTD-MPN2006-2010-143035)
У:
- Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia. Belgrade: Serbian Physiology Society; 2006. p. 33.