Приказ основних података о документу
Inducible nitric oxide synthase activation by interleukin-17
dc.creator | Miljković, Đorđe | |
dc.creator | Trajković, Vladimir | |
dc.date.accessioned | 2023-07-31T10:45:45Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2004 | |
dc.identifier.issn | 1359-6101 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6010 | |
dc.description.abstract | Interleukin-17 (IL-17) is a proinflammatory T cell cytokine presumably involved in physiological responses to infection, but also in immunopathology of autoimmune disorders such as rheumatoid arthritis. The proinflammatory action of IL-17 depends considerably on its ability to trigger the expression of inducible nitric oxide (NO) synthase (iNOS), an enzyme responsible for the generation of cytotoxic and immunoregulatory free radical NO. Here we discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze signaling pathways employed by IL-17 for the initiation of iNOS gene transcription. We also propose biological consequences of IL-17-mediated NO release that could be relevant for the mechanisms or therapy of autoimmune and inflammatory disorders. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | Ministry of Science and Technology of the Republic of Serbia (Grants No. 1664 and 2020) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Cytokine and Growth Factor Reviews | sr |
dc.subject | Nitric oxide | sr |
dc.subject | iNOS | sr |
dc.subject | Autoimmunity | sr |
dc.title | Inducible nitric oxide synthase activation by interleukin-17 | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2003 Elsevier Ltd. | sr |
dc.citation.issue | 1 | |
dc.citation.volume | 15 | |
dc.identifier.doi | 10.1016/j.cytogfr.2003.10.003 | |
dc.identifier.pmid | 14746811 | |
dc.identifier.scopus | 2-s2.0-1642554789 | |
dc.identifier.wos | 000220870300003 | |
dc.citation.spage | 21 | |
dc.citation.epage | 32 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | aM21 |