Novel platinum(IV) complexes induce rapid tumor cell death in vitro
2005
Autori:
Kaluđerović, GoranMiljković, Đorđe
Momčilović, Miljana
Đinović, Vesna
Mostarica Stojković, Marija
Sabo, Tibor
Trajković, Vladimir
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2005 Wiley‐Liss, Inc.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy.
Ključne reči:
platinum(IV); cisplatin; apoptosis; necrosis; oxidative stressIzvor:
International Journal of Cancer, 2005, 116, 3, 479-486Finansiranje / projekti:
- Ministry of Science and Environmental Protection of the Republic of Serbia; Grant number: 1253, 1664 and 2020.
DOI: 10.1002/ijc.21080
ISSN: 0020-7136
PubMed: 15818622