Приказ основних података о документу
Novel platinum(IV) complexes induce rapid tumor cell death in vitro
dc.creator | Kaluđerović, Goran | |
dc.creator | Miljković, Đorđe | |
dc.creator | Momčilović, Miljana | |
dc.creator | Đinović, Vesna | |
dc.creator | Mostarica Stojković, Marija | |
dc.creator | Sabo, Tibor | |
dc.creator | Trajković, Vladimir | |
dc.date.accessioned | 2023-07-31T12:25:39Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6014 | |
dc.description.abstract | The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. | sr |
dc.language.iso | en | sr |
dc.publisher | John Wiley and Sons | sr |
dc.relation | Ministry of Science and Environmental Protection of the Republic of Serbia; Grant number: 1253, 1664 and 2020. | sr |
dc.rights | restrictedAccess | sr |
dc.source | International Journal of Cancer | sr |
dc.subject | platinum(IV) | sr |
dc.subject | cisplatin | sr |
dc.subject | apoptosis | sr |
dc.subject | necrosis | sr |
dc.subject | oxidative stress | sr |
dc.title | Novel platinum(IV) complexes induce rapid tumor cell death in vitro | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2005 Wiley‐Liss, Inc. | sr |
dc.citation.issue | 3 | |
dc.citation.volume | 116 | |
dc.identifier.doi | 10.1002/ijc.21080 | |
dc.identifier.pmid | 15818622 | |
dc.identifier.scopus | 2-s2.0-22244452610 | |
dc.identifier.wos | 000230466100021 | |
dc.citation.spage | 479 | |
dc.citation.epage | 486 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M21 |