Cucurbitacin E Potently Modulates the Activity of Encephalitogenic Cells
2016
Autori:
Jevtić, BojanNikolovski, Neda
Stanisavljević, Suzana
Despotović, Jovana
Miljković, Đorđe
Timotijević, Gordana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2016 American Chemical Society
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Cucurbitacin E (CucE) is a highly oxidized steroid consisting of a tetracyclic triterpene. It is a member of a Cucurbitacin family of biomolecules that are predominantly found in Cucurbitaceae plants. CucE has already been identified as a potent anti-inflammatory compound. Here, its effects on CD4(+) T helper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system, were investigated. Production of major pathogenic Th cell cytokines: interferon-gamma and interleukin-17 were inhibited under the influence of CucE. The effects of CucE on CD4(+) T cells were mediated through the modulation of aryl hydrocarbon receptor, STAT3, NFκB, p38 MAPK, and miR-146 signaling. Further, production of nitric oxide and reactive oxygen species, as well as phagocytic ability, were inhibited in macrophages treated with CucE. These results imply that CucE possesses powerful antiencephalitogenic activity.
Ključne reči:
cucurbitacin E; T cell; macrophage; autoimmunity; experimental autoimmune encephalomyelitisIzvor:
Journal of Agricultural and Food Chemistry, 2016, 64, 24, 4900-4907Finansiranje / projekti:
- Ćelijski i molekulski mehanizmi oporavka pacova od eksperimentalnog autoimunskog encefalomijelitisa (RS-MESTD-Basic Research (BR or ON)-173035)
- Molekularni mehanizmi odgovora biljaka na abiotički stres-uloga transkripcionih faktora i malih RNK i analiza genetičkog diverziteta biljnih kultura od interesa za poljoprivredu i biotehnologiju (RS-MESTD-Basic Research (BR or ON)-173005)
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Kompleksne bolesti kao model sistem za proučavanje modulacije fenotipa-strukturna i funkcionalna analiza molekularnih biomarkera (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1021/acs.jafc.6b00951
ISSN: 0021-8561
PubMed: 27225664