Effects of two different types of training on morphometric parameters of the left ventricle miocardium in normotensive and hipertensive rats
2018
Autori:
Sretenović, JasminaJakovljević, Biljana
Živković, Vladimir
Srejović, Ivan
Ajdžanović, Vladimir
Milošević, Verica
Jakovljević, Vladimir
Ostala autorstva
Jakovljević, VladimirBolevich, Sergey
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
,
© 2018 by the University of Kragujevac, Faculty of Medical Sciences
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The aim of this study was to show the effects of moderate-intensity and high-intensity training on morfometric parameters of the left ventricle miocardium in normotensive and hypertensive rats. The study included 32-male Wistar albino and spontaneously hypertensive rats, divided into 6 groups: control normotensive (CTRL), normotensive moderate-intensity training (MIT), normotensive high-intensity training (HIIT), control hypertensive (SHR), hypertensive moderate-The rat ton Mist Roups and by peaterive high since sit training (Si HI days/week, Ih/day, while HIIT groups ran on speed from 35 to 55m/min, 30s in 5 cycles, with a 3 min period of rest between the cycles. After 4-weeks of training, the rats were sacrificed. Heart biopsy specimens were routinely fixed and embedded in paraffin. Five micrometer thick sections were H&E stained. Captured microscopic images were processed by special software for image analysis to quantify the results. Body weights were decreased in all groups of hypertensive rats compared to normotensive rats. Relative heart weights were increased in hypertensive rats compared to normotensive rats. Longitudinal section diameter of cardiac muscle cells was decreased in SHR-MIT group for 13% compared to MIT, while in SHR-HIIT group the same parameter decreased for 17% compared to HIIT. Cross section muscle cell area was decreased: in SHR fl 7% compared to CTRL, in SHR-MIT for 6% compared to MIT, and in SHR-HIIT for 9% in comparison with HIIT. Both types of training caused significant hypertrophy of the left ventricle myocardium in normotensive and hypertensive rats
Finansiranje / projekti:
- Odgovor neuroendokrinog sistema pacova na odabrane biljne ekstrakte, fitoestrogene, steroidne i peptidne hormone (RS-MESTD-Basic Research (BR or ON)-173009)
U:
- Jakovljević V, Bolevich S, editors. Final program and abstract book: 8th International Congress of Pathophysiology, Satelite Symposium: Oxidative Stress in Health and Disease: from Basic Science to Applied Investigations; 2018 Sep 03; Kragujevac, Serbia. Kragujevac: University of Kragujevac, Faculty of Medical Sciences; 2018. p. 32.