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Defining the ferroptotic phenotype of beta cells in type 1 diabetes and its inhibition as a potential antidiabetic strategy
dc.creator | Markelić, Milica | |
dc.creator | Stančić, Ana | |
dc.creator | Saksida, Tamara | |
dc.creator | Grigorov, Ilijana | |
dc.creator | Mićanović, Dragica | |
dc.creator | Veličković, Ksenija | |
dc.creator | Martinović, Vesna | |
dc.creator | Savić, Nevena | |
dc.creator | Gudelj, Anđelija | |
dc.creator | Otašević, Vesna | |
dc.date.accessioned | 2023-09-26T13:45:30Z | |
dc.date.available | 2023-09-26T13:45:30Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1664-2392 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6071 | |
dc.description.abstract | Introduction: Recently, the involvement of ferroptotic cell death in the reduction of β-cell mass in diabetes has been demonstrated. To elucidate the mechanisms of β-cell ferroptosis and potential antidiabetic effects of the ferroptosis inhibitor ferrostatin-1 (Fer-1) in vivo, a mouse model of type 1 diabetes (T1D) was used. Methods: Animals were divided into three groups: control (vehicle-treated), diabetic (streptozotocin-treated, 40 mg/kg, from days 1-5), and diabetic treated with Fer-1 (1 mg/kg, from days 1-21). On day 22, glycemia and insulinemia were measured and pancreases were isolated for microscopic analyses. Results: Diabetes disturbed general parameters of β-cell mass (islet size, β-cell abundance and distribution) and health (insulin and PDX-1 expression), increased lipid peroxidation in islet cells, and phagocytic removal of iron-containing material. It also downregulated the main players of the antiferroptotic pathway - Nrf2, GPX4, and xCT. In contrast, Fer-1 ameliorated the signs of deterioration of β-cell/islets, decreased lipid peroxidation, and reduced phagocytic activity, while upregulated expression of Nrf2 (and its nuclear translocation), GPX4, and xCT in β-cell/islets. Discussion: Overall, our study confirms ferroptosis as an important mode of β-cell death in T1D and suggests antiferroptotic agents as a promising strategy for the prevention and treatment of diabetes | sr |
dc.language.iso | en | sr |
dc.publisher | Lausanne: Frontiers Media SA | sr |
dc.relation | 6525651‚Program saradnje srpske nauke sa dijasporom: Vaučeri za razmenu znanja, Fond za nauku Republike Srbije | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Frontiers in Endocrinology | sr |
dc.subject | ferroptosis | sr |
dc.subject | β-cell death | sr |
dc.subject | diabetes | sr |
dc.subject | ferroptosis inhibitor | sr |
dc.subject | ferrostatin-1 | sr |
dc.title | Defining the ferroptotic phenotype of beta cells in type 1 diabetes and its inhibition as a potential antidiabetic strategy | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.rights.holder | © 2023 Markelic, Stancic, Saksida, Grigorov, Micanovic, Velickovic, Martinovic, Savic, Gudelj and Otasevic. | sr |
dc.citation.volume | 14 | |
dc.identifier.doi | 10.3389/fendo.2023.1227498 | |
dc.identifier.pmid | 37600723 | |
dc.identifier.scopus | 2-s2.0-85168270023 | |
dc.identifier.wos | 001050281400001 | |
dc.citation.apa | Markelic, M., Stancic, A., Saksida, T., Grigorov, I., Micanovic, D., Velickovic, K., et al. (2023). Defining the ferroptotic phenotype of beta cells in type 1 diabetes and its inhibition as a potential antidiabetic strategy. Frontiers in Endocrinology, 14, 1227498. | |
dc.citation.vancouver | Markelic M, Stancic A, Saksida T, Grigorov I, Micanovic D, Velickovic K, Martinovic V, Savic N, Gudelj A, Otasevic V. Defining the ferroptotic phenotype of beta cells in type 1 diabetes and its inhibition as a potential antidiabetic strategy. Front Endocrinol (Lausanne). 2023;14:1227498. | |
dc.citation.spage | 1227498 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/14664/fendo-14-1227498.pdf | |
dc.citation.rank | M21 |