Paeonia peregrina Mill Petals as a New Source of Biologically Active Compounds: Chemical Characterization and Skin Regeneration Effects of the Extracts
2023
Authors:
Marković, TatjanaČutović, Natalija
Carević, Tamara
Gašić, Uroš
Stojković, Dejan
Xue, Jingqi
Jovanović, Aleksandra
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Paeonia peregrina Mill. is a perennial herbaceous plant species, known for the medicinal value of all of its plant parts, although the chemical composition of the petals is unknown. This study aimed to determine the chemical fingerprint of the petals and also establish the optimal extraction parameters, extraction medium, and extraction method for petals collected from different localities in Serbia. The optimization was performed in order to acquire extracts that are rich in the contents of total polyphenol content (TPC) and total flavonoid content (TFC), and also exhibit strong antioxidant activity. In addition, the influence of the extracts on several human skin pathogens was evaluated, as well as their ability to aid wound closure and act as anti-inflammatory agents. Both the extraction medium and the applied technique significantly influenced the skin-beneficial biological activities, while methanol proved to be a more favorable extraction medium. In conclusion, the extraction conditions that yielded the extract with the richest phenolic content with satisfactory biological potential varied between the assays, while the most promising locality in Serbia for the collection of P. peregrina petals was Pančevo (South Banat).
Keywords:
petals; herbaceous peony; biological activities; chemical compositionSource:
International Journal of Molecular Sciences, 2023, 24, 14, 11764-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200019 (University of Belgrade, Institute for the Application of Nuclear Energy - INEP) (RS-MESTD-inst-2020-200019)
- National Key R&D Program of China (2021YFE0110700)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia (451-03-1202/2021-09/3)
DOI: 10.3390/ijms241411764
ISSN: 1661-6596
PubMed: 37511520