Antitumor potential of novel triphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands
2023
Authors:
Jelača, SanjaKasalović, Marijana P.
Pantelić, Nebojša Đ.
Kaluđerović, Goran N.
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Contributors
Spasojević, IvanDocument Type:
Conference object (Published version)
,
© 2023 by the Faculty of Chemistry, University of Belgrade
Metadata
Show full item recordAbstract:
Cancer is responsible for millions of deaths worldwide each year and, although great
advances have been made in the treatment options, there are still many issues that must be
addressed in order to improve cancer therapy. In the present work, anticancer effect of
three novel Ph3 SnL complexes (L1 –,3-(4-methyl-2-oxoquinolinyl-1(2H)-yl)propanoato;
L2 –,2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato; L3 –,2-(4-hydroxy-2-oxoquinolin-
1(2H)-yl)ethanoato), was evaluated against several cancer cell lines (MCA-7, A375,
HCT116, 4T1, B16 and CT26). The applied treatment decreased cell viability of all cell
lines after 72 h in a dose-dependent manner with IC50 values in the low micromolar range.
Flow cytometric assessment revealed apoptotic cell death in A375 but not B16 culture,
exposed to tested drug. Morphological signs of apoptosis such as shrunk nuclei and
condensed chromatin were further confirmed by fluorescent microscopy. Same treatment
in B16 lead to cell division block coupled with two-fold increase in the amount of melanin
and tyrosinase activity, indicating the differentiation of B16 cells towards melanocytes. In
the background of different response of two melanoma cell lines lies dissimilar redox
response to the treatment. While in A375 cultures, ROS/RNS production is inhibited in
comparison to control, in B16 cells compound Ph3SnL1 provokes ROS/RNS generation.
Finally, when applied in therapeutic regiment, Ph3SnL1 significantly reduced tumor
volume in C57BL/6 mice.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
In:
- Spasojević I, editor. Biochemistry in Biotechnology: Serbian Biochemical Society, Twelfth Conference, International scientific meeting; 2023 Sep 21-23; Belgrade, Serbia. Belgrade: Faculty of Chemistry; 2023. p. 95.