The Effects of Endocrine Disruptors on Female Gonadal Axis: an Update
2023
Аутори:
Macut, ĐuroOpalić, Milica
Popović, Bojana
Ognjanović, Sanja
Bjekić-Macut, Jelica
Livadas, Sarantis
Petrović, Tijana
Hrnčić, Dragan
Stanojlović, Olivera
Vojnović Milutinović, Danijela
Micić, Dragan
Mastorakos, George
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2023 by the Acta Endocrinologica Foundation
Метаподаци
Приказ свих података о документуАпстракт:
Endocrine disruptors (EDs) are considered to have an impact on the function of reproductive axis at different levels as well on reproductive organs in both sexes. Complexity of female reproductive system influenced with various stressors including EDs lead to morphological and functional alterations. This is resulting in modulation of neuroendocrine regulation with consequent developmental irregularities and derangements, causative infertility, endometriosis as well as premature ovarian insufficiency or polycystic ovary syndrome. A number of experimental clues was obtained on female animal models using various EDs such as synthetic estrogens and phytoestrogens, neurotransmitters, pesticides or various chemicals. These substances lead towards consequent derangement of the neuroendocrine control of reproduction from early phases of reproductive development towards different phases of adult reproductive period. This text will address some novel insights into the effects of EDs on neuroendocrine regulation of gonadal axis, effects on ovaries as well on endometrium during implantation period.
Кључне речи:
endocrine disruptors; female reproduction; infertility; neuroendocrine regulation; ovary; endometrium; implantationИзвор:
Acta Endocrinologica (Bucharest), 2023, 19, 1, 81-86Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
DOI: 10.4183/aeb.2023.81
ISSN: 1841-0987
PubMed: 37601725