dc.creator | Todorović, Smilja | |
dc.creator | Simeunović, Valentina | |
dc.creator | Prvulović, Milica | |
dc.creator | Dakić, Tamara | |
dc.creator | Jevđović, Tanja | |
dc.creator | Sokanović, Srđan | |
dc.creator | Kanazir, Selma | |
dc.creator | Mladenović, Aleksandra | |
dc.date.accessioned | 2023-12-01T12:02:58Z | |
dc.date.available | 2024-11-17 | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0951-6433 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6373 | |
dc.description.abstract | Insulin is known to be a key hormone in the regulation of peripheral glucose homeostasis, but beyond that, its effects on the brain are now undisputed. Impairments in insulin signaling in the brain, including changes in insulin levels, are thought to contribute significantly to declines in cognitive performance, especially during aging. As one of the most widely studied experimental interventions, dietary restriction (DR) is considered to delay the neurodegenerative processes associated with aging. Recently, however, data began to suggest that the onset and duration of a restrictive diet play a critical role in the putative beneficial outcome. Because the effects of DR on insulin signaling in the brain have been poorly studied, we decided to examine the effects of DR that differed in onset and duration: long-term DR (LTDR), medium-term DR (MTDR), and short-term DR (STDR) on the expression of proteins involved in insulin signaling in the hippocampus of 18- and 24-month-old male Wistar rats. We found that DR-induced changes in insulin levels in the brain may be independent of what happens in the periphery after restricted feeding. Significantly changed insulin content in the hippocampus, together with altered insulin signaling were found under the influence of DR, but the outcome was highly dependent on the onset and duration of DR. | sr |
dc.language.iso | en | sr |
dc.publisher | Hoboken: John Wiley and Sons | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | embargoedAccess | sr |
dc.source | Biofactors | sr |
dc.subject | aging | sr |
dc.subject | dietary restriction | sr |
dc.subject | durration | sr |
dc.subject | hippocampus | sr |
dc.subject | insulin | sr |
dc.subject | insulin receptor | sr |
dc.subject | onset | sr |
dc.title | Dietary restriction alters insulin signaling pathway in the brain | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2023 International Union of Biochemistry and Molecular Biology | sr |
dc.description.note | This is the peer reviewed version of the following article: Todorovic S, Simeunovic V, Prvulovic M, Dakic T, Jevdjovic T, Sokanovic S, Kanazir S, Mladenovic A. Dietary restriction alters insulin signaling pathway in the brain. BioFactors. 2023, which has been published in final form at [http://dx.doi.org/10.1002/biof.2018].
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |
dc.identifier.doi | 10.1002/biof.2018 | |
dc.identifier.pmid | 37975613 | |
dc.identifier.scopus | 2-s2.0-85177092798 | |
dc.citation.vancouver | Todorovic S, Simeunovic V, Prvulovic M, Dakic T, Jevdjovic T, Sokanovic S, Kanazir S, Mladenovic A. Dietary restriction alters insulin signaling pathway in the brain. BioFactors. 2023; | |
dc.type.version | acceptedVersion | sr |
dc.citation.rank | M21~ | |