Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity
2024
Аутори:
Vukčević, MarijaŠerović, Katarina
Despot, Mateja
Nikolić-Kokić, Aleksandra
Vujović, Aleksandra
Nikolić, Milan
Blagojević, Duško
Jovanović, Tanja
Despot, Dragana
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Background: Several vaccines against COVID-19 have been developed and licensed to
enhance the immune response against SARS-CoV-2. Similarly, previous infection with SARS-CoV-
2 has been shown to provide significant protection against severe infection and hospitalization.
Methods: We investigated the effect of three doses of the Sinopharm vaccine and SARS-CoV-2
infection on the specific immune response in 103 volunteers, measuring neutralizing antibodies, anti-
S1 IgG, anti-RBD IgM, anti-N IgM, anti-N IgG antibodies, and INF γ. Results: Our results showed
that the presence of cardiovascular diseases increased the level of anti-N-IgG antibodies, while
endocrinological diseases decreased the level of neutralizing antibodies and anti-N IgG antibodies,
suggesting that these diseases alter the effect of vaccine-induced immunity. In addition, there was a
significant decrease in anti-S1 IgG levels at 6 months and in anti-N IgG levels 18 months post-infection,
while neutralizing antibodies and INF γ levels were constant at 3, 6, and 18 months post-infection.
Conclusions: Our results confirm the emergence of hybrid immunity, which is the strongest and
most durable compared to natural immunity or vaccine-induced immunity. Significant positive
correlations were found between humoral and cellular immunity markers: neutralizing antibodies,
anti-S1 IgG and anti-N IgG antibodies, and INF γ, indicating a unique coordinated response specific
to COVID-19.
Кључне речи:
COVID-19; Sinopharm vaccine; neutralizing antibodies; anti-S1 IgG antibodies; anti-RBD IgM antibodies; anti-N IgM antibodies; anti-N IgG antibodies; INF γИзвор:
Pharmaceuticals, 2024, 17, 1, 122-Институција/група
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