Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance
2024
Аутори:
Popov Aleksandrov, Aleksandra![](/themes/MirageIBISS/images/orcid.png)
Tucović, Dina
![](/themes/MirageIBISS/images/orcid.png)
Kulaš, Jelena
![](/themes/MirageIBISS/images/orcid.png)
Popović, Dušanka
![](/themes/MirageIBISS/images/orcid.png)
Kataranovski, Dragan
Kataranovski, Milena
![](/themes/MirageIBISS/images/orcid.png)
Mirkov, Ivana
![](/themes/MirageIBISS/images/orcid.png)
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2024 Elsevier Inc.
Метаподаци
Приказ свих података о документуАпстракт:
The use of anticoagulant rodenticides (ARs) is one of the most commonly employed management methods for
pest rodents. ARs compete with vitamin K (VK) required for the synthesis of blood clotting factors in the liver,
resulting in inhibition of blood coagulation and often animal death due to hemorrhage. Besides rodents (target
species), ARs may affect non-target animal species and humans. Out of hemostasis disturbance, the effects of ARs
may be related to the inhibition of proteins that require VK for their synthesis but are not involved in the
coagulation process, to their direct cytotoxicity, and their pro-oxidant/proinflammatory activity. A survey of the
cellular and molecular mechanisms of these sublethal/asymptomatic AR effects is given in this review. Data from
field, clinical, and experimental studies are presented. Knowledge of these mechanisms might improve hazard
characterization and identification of potential ecotoxicological risks associated with ARs, contributing to a safer
use of these chemicals.
Кључне речи:
Anticoagulant rodenticides; Vitamin K antagonism; Effects unrelated to hemostasis; Direct cytotoxicity; Pro-oxidant/pro-inflammatory activityИзвор:
Comparative Biochemistry and Physiology, Part C, 2024, 277, 109841-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.1016/j.cbpc.2024.109841
ISSN: 1532-0456
PubMed: 38237840