Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe
2024
Аутори:
Santoro, AzzurraSantolamazza, Federica
Cacciò, Simone
La Rosa, Giuseppina
Antolová, Daniela
Auer, Herbert
Bagrade, Guna
Bandelj, Petra
Basso, Walter
Beck, Relja
Citterio, Carlo
Davidson, Rebecca
Deksne, Gunita
Frey, Caroline
Fuglei, Eva
Glawischnig, Walter
Gottstein, Bruno
Harna, Jiri
Petersen, Heidi
Karamon, Jacek
Jansen, Famke
Jarošová, Júlia
Jokelainen, Pikka
Lundström-Stadelmann, Britta
Maksimov, Pavlo
Miljević, Milan
Miterpáková, Martina
Moks, Epp
Origgi, Francesco
Ozolina, Zanda
Ryser, Marie-Pierre
Romig, Thomas
Šarkūnas, Mindaugas
Scorrano, Nathalie
Saarma, Urmas
Šnábel, Viliam
Sréter, Tamas
Umhang, Gerald
Vengušt, Gorzad
Žele Vengušt, Diana
Casulli, Adriano
Тип документа:
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The cestode Echinococcus multilocularis is the causative agent of alveolar echinococcosis, a fatal zoonotic parasitic disease of the northern hemisphere. Red foxes are the main reservoir hosts and, likely, the main drivers of the geographic spread of the disease in Europe. Knowledge of genetic relationships among E. multilocularis isolates at a European scale is key to understanding the dispersal characteristics of E. multilocularis. Hence, the present study aimed to describe the genetic diversity of E. multilocularis isolates obtained from different host species in 19 European countries. Based on the analysis of complete nucleotide sequences of the cob, atp6, nad2, nad1 and cox1 mitochondrial genes (4,968 bp), 43 haplotypes were inferred. Four haplotypes represented 62.56 % of the examined isolates (142/227), and one of these four haplotypes was found in each country investigated, except Svalbard, Norway. While the haplotypes from Svalbard were markedly different from all the others, mainland Europe appeared to be dominated by two main clusters, represented by most western, central and eastern European countries, and the Baltic countries and northeastern Poland, respectively. Moreover, one Asian-like haplotype was identified in Latvia and northeastern Poland. To better elucidate the presence of Asian genetic variants of E. multilocularis in Europe, and to obtain a more comprehensive Europe-wide coverage, further studies, including samples from endemic regions not investigated in the present study, especially some eastern European countries, are needed. Further, the present work proposes historical causes that may have contributed to shaping the current genetic variability of E. multilocularis in Europe