The complex relationship between late-onset caloric restriction and synaptic plasticity in aged Wistar rats
2024
Аутори:
Prvulović, MilicaSokanović, Srđan
Simeunović, Valentina
Vukojević, Anđela
Jović, Milena
Todorović, Smilja
Mladenović, Aleksandra
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2024 International Union of Biochemistry and Molecular Biology.
Метаподаци
Приказ свих података о документуАпстракт:
Age-related reduction in spine density, synaptic marker expression, and synaptic efficiency are frequently reported. These changes provide the cellular and
molecular basis for the cognitive decline characteristic for old age. Nevertheless, there are several approaches that have the potential to ameliorate these
processes and improve cognition, caloric restriction being one of the most
promising and widely studied. While lifelong caloric restriction is known for
its numerous beneficial effects, including improved cognitive abilities and
increased expression of proteins essential for synaptic structure and function,
the effects of late-onset and/or short-term CR on synaptic plasticity have yet to
be investigated. We have previously documented that the effects of CR are
strongly dependent on whether CR is initiated in young or old subjects. With
this in mind, we conducted a long-term study in aging Wistar rats to examine
changes in the expression of several key synaptic markers under the regimen
of CR started at different time points in life. We found a significant increase in
the expression of both presynaptic and postsynaptic markers. However, taking
into account previously reported changes in the behavior detected in these animals, we consider that this increase cannot represent beneficial effect of CR.
Кључне речи:
aging; brain; caloric restriction; synaptic markers; synaptic plasticityИзвор:
IUBMB Life, 2024Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
Повезане информације:
- Друга верзија
https://radar.ibiss.bg.ac.rs/handle/123456789/6586
DOI: 10.1002/iub.2812
ISSN: 1521-6543
PubMed: 38390757