Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management
2017
Аутори:
Janković, Aleksandra![](/themes/MirageIBISS/images/orcid.png)
Korać, Aleksandra
Buzadžić, Biljana
Stančić, Ana
![](/themes/MirageIBISS/images/orcid.png)
Otašević, Vesna
![](/themes/MirageIBISS/images/orcid.png)
Ferdinandy, Peter
Daiber, Andreas
Korać, Bato
![](/themes/MirageIBISS/images/orcid.png)
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2016 The British Pharmacological Society
Метаподаци
Приказ свих података о документуАпстракт:
Insulin sensitivity and metabolic homeostasis depend on the capacity of adipose tissue to take up and utilize excess glucose and fatty acids. The key aspects that determine the fuel‐buffering capacity of adipose tissue depend on the physiological levels of the small redox molecule, nitric oxide (NO). In addition to impairment of NO synthesis, excessive formation of the superoxide anion (О2 •–) in adipose tissue may be an important interfering factor diverting the signalling of NO and other reactive oxygen and nitrogen species in obesity, resulting in metabolic dysfunction of adipose tissue over time. Besides its role in relief from superoxide burst, enhanced NO signalling may be responsible for the therapeutic benefits of different superoxide dismutase mimetics, in obesity and experimental diabetes models. This review summarizes the role of NO in adipose tissue and highlights the effects of NO/О2 •– ratio ‘teetering’ as a promising pharmacological target in the metabolic syndrome.
Извор:
British Journal of Pharmacology, 2017, 174, 12, 1570-1590Финансирање / пројекти:
- European Cooperation in Science and Technology (COST Action BM1203/EU-ROS).
- Бело или/и мрко: значај масног ткива у одржању укупне редокс зависне метаболичке контроле у физиолошким адаптацијама и метаболичким поремећајима (RS-MESTD-Basic Research (BR or ON)-173055)
DOI: 10.1111/bph.13498
ISSN: 0007-1188
PubMed: 27079449