In vitro avarol does affect the growth of Candida sp.
2016
Document Type:
Article (Published version)
,
© 2015 taylor & Francis
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Show full item recordAbstract:
This work extends in vitro screening of antimicrobial activity of avarol,
the marine natural product firstly isolated from the Mediterranean
sponge Dysidea avara. Its anticandidial activity was evaluated by
microdilution method against eight Candida strains, two ATCC and
six clinical ones. At a different extent this compound was proven to be
active against all the strains tested (MIC 0.8–6.0 μg/mL and MFC 1.6–
12.0 μg/mL, respectively). According to the best of our knowledge,
this is the first report on avarol activity towards any yeast strain
which may be of relevance for Alzheimer’s disease. Indeed, avarol
derivatives showing moderate AChE activity should be screened for
anticandidial activity both in vitro and in vivo.
Keywords:
Marine sponge; Dysidea avara; avarol; oral pathogenes; anticandidal activty; Alzheimer’s diseaseSource:
Natural Product Research, 2016, 30, 7, 1956-1960Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Synthesis and biological testing of new mimics or derivatives of selected cytotoxic lactones, antitumor agent tiazofurin and natural naphthenic acids (RS-MESTD-Basic Research (BR or ON)-172006)
DOI: 10.1080/14786419.2015.1091454
ISSN: 1478-6419
PubMed: 26405848