In vitro avarol does affect the growth of Candida sp.
2016
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2015 taylor & Francis
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
This work extends in vitro screening of antimicrobial activity of avarol,
the marine natural product firstly isolated from the Mediterranean
sponge Dysidea avara. Its anticandidial activity was evaluated by
microdilution method against eight Candida strains, two ATCC and
six clinical ones. At a different extent this compound was proven to be
active against all the strains tested (MIC 0.8–6.0 μg/mL and MFC 1.6–
12.0 μg/mL, respectively). According to the best of our knowledge,
this is the first report on avarol activity towards any yeast strain
which may be of relevance for Alzheimer’s disease. Indeed, avarol
derivatives showing moderate AChE activity should be screened for
anticandidial activity both in vitro and in vivo.
Ključne reči:
Marine sponge; Dysidea avara; avarol; oral pathogenes; anticandidal activty; Alzheimer’s diseaseIzvor:
Natural Product Research, 2016, 30, 7, 1956-1960Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Sinteza i biološka ispitivanja novih mimetika ili derivata odabranih citotoksičnih laktona, antitumorskog agensa tiazofurina i prirodnih naftnih kiselina (RS-MESTD-Basic Research (BR or ON)-172006)
DOI: 10.1080/14786419.2015.1091454
ISSN: 1478-6419
PubMed: 26405848