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A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
dc.creator | Trmčić, Milena V. | |
dc.creator | Matović, Radomir V. | |
dc.creator | Tovilović-Kovačević, Gordana | |
dc.creator | Ristić, Biljana Z. | |
dc.creator | Trajković, Vladimir S. | |
dc.creator | Ferjančić, Zorana B. | |
dc.creator | Saičić, Radomir N. | |
dc.date.accessioned | 2024-06-17T11:20:07Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6839 | |
dc.description.abstract | The design, synthesis and biological evaluation of a novel C,D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G2/M cell cycle arrest-dependent apoptosis. | sr |
dc.language.iso | en | sr |
dc.publisher | Cambridge: Royal Soc Chemistry | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172027/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Organic and Biomolecular Chemistry | sr |
dc.subject | C,D-spirolactone derivatives | sr |
dc.subject | Paclitaxel | sr |
dc.subject | Cytotoxic | sr |
dc.subject | Autophagy | sr |
dc.subject | mTOR inhibition | sr |
dc.title | A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2012 by The Royal Society of Chemistry | sr |
dc.citation.issue | 25 | |
dc.citation.volume | 10 | |
dc.identifier.doi | 10.1039/c2ob25514f | |
dc.identifier.pmid | 22614284 | |
dc.identifier.scopus | 2-s2.0-84862224265 | |
dc.identifier.wos | 000304885200015 | |
dc.citation.spage | 4933 | |
dc.citation.epage | 4942 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M21 |