Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses
2024
Аутори:
Manojlović-Stojanoski, MilicaBorković-Mitić, Slavica
Nestorović, Nataša
Ristić, Nataša
Stefanović, Radomir
Stevanović, Magdalena
Filipović, Nenad
Stojsavljević, Aleksandar
Pavlović, Slađan
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
To compare the effects of organic selenium nanoparticles (SeNPs, Se0) and inorganic
sodium selenite (NaSe, Na2SeO3, Se4+) on the antioxidant response in maternal and fetal rat liver,
pregnant females were treated with two forms of selenium (Se) at equivalent doses during gestation
(0.5 mg SeNPs or 0.5 mg NaSe/kg body weight/day). Structural parameters of the liver of gravid
females and their fetuses were examined in a sex-specific manner. The oxidative stress parameters
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase
(GR), glutathione S-transferase (GST), total glutathione (GSH) and sulfhydryl groups (SH) were
established. In addition, the Se concentration was determined in the blood, liver, urine and feces
of the gravid females and in the liver of the fetuses. The structure of the liver of gravid females
remained histologically the same after supplementation with both forms of Se, while the oxidative
stress in the liver was significantly lower after the use of SeNPs compared to NaSe. Immaturity of
fetal antioxidant defenses and sex specificity were demonstrated. This study provides a detailed
insight into the differences in the bioavailability of the nano form of Se compared to sodium selenite
in the livers of pregnant females and fetuses.
Кључне речи:
antioxidant response; selenium nanoparticles; sodium selenite; pregnancy; fetuses; liver; histology; oxidative stress parameters; sex differencesИзвор:
Antioxidants, 2024, 13, 7, 756-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200175 (Институт техничких наука САНУ, Београд) (RS-MESTD-inst-2020-200175)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)