dc.creator | Isaković, Aleksandra | |
dc.creator | Marković, Zoran | |
dc.creator | Nikolić, Nadežda | |
dc.creator | Todorović-Marković, Biljana | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.creator | Harhaji-Trajković, Ljubica | |
dc.creator | Zogović, Nevena | |
dc.creator | Romčević, Nebojša | |
dc.creator | Vasiljević-Radović, Dana | |
dc.creator | Dramićanin, Miroslav | |
dc.creator | Trajković, Vladimir | |
dc.date.accessioned | 2024-08-13T09:30:49Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0142-961 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6946 | |
dc.description.abstract | We investigated the effect of gamma-irradiation on the cytotoxicity of pure C60 solubilized in water by using tetrahydrofuran (THF/n-C60 or THF/n-C60). In contrast to THF/n-C60, its gamma-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, gamma-irradiated THF/n-C60 protected cells from the oxidative stress induced by native THF/n-C60 or hydrogen peroxide. The observed biological effects were associated with gamma-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C60 surface. These results for the first time demonstrate gamma-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145073/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Biomaterials | sr |
dc.title | Inactivation of nanocrystalline C60 cytotoxicity by γ-irradiation | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2006 by Elsevier Ltd. | sr |
dc.citation.issue | 29 | |
dc.citation.volume | 27 | |
dc.identifier.doi | 10.1016/j.biomaterials.2006.05.047 | |
dc.identifier.pmid | 16784774 | |
dc.identifier.scopus | 2-s2.0-33745272220 | |
dc.identifier.wos | 000240167500005 | |
dc.citation.spage | 5049 | |
dc.citation.epage | 5058 | |
dc.type.version | publishedVersion | sr |