C/EBPα and C/EBPβ are persistently associated with the rat liver nuclear matrix throughout development and the acute phase response
2000
Authors:
Dinić, SvetlanaIvanović-Matić, Svetlana
Bogojević, Desanka
Mihailović, Mirjana
Poznanović, Goran
Document Type:
Article (Published version)
,
© 2000 Academic Press
Metadata
Show full item recordAbstract:
The partitioning of C/EBPalpha and C/EBPbeta on the nuclear matrix structure was examined during the different transcriptional activities accompanying liver development and the acute phase (AP) response. The presence of C/EBPalpha and C/EBPbeta was established on the nuclear matrix. Their relative concentrations on the matrix always reflected the developmental stage- and AP-related fluctuations observed in the nuclear extract. Thus, they progressively increased as development proceeded, whereas during the AP response, C/EBPalpha decreased and C/EBPbeta increased. In addition, the levels of both transcription factors were always notably higher in the nuclear matrix than in the extracts. We conclude that the observed changes and overall enrichment of the nuclear matrix with regulatory proteins is a reflection of the importance of such interactions for the in vivo functioning of C/EBP proteins.
Keywords:
nuclear matrix;; CCAAT/enhancer-binding proteins (C/EBP)alpha and beta;; acute phase (AP)responseSource:
Cell Biology International, 2000, 24, 10, 691-698Funding / projects:
- Research ScienceFund of the Serbian Ministry of Science, ContractNo. 03E20
DOI: 10.1006/cbir.2000.0531
ISSN: 1065-6995
PubMed: 11023646