Mitigating the effects of time in the heart and liver: The variable effects of short- and long-term caloric restriction
2024
Authors:
Prvulović, MilicaPavlović, Slađan
Borković Mitić, Slavica
Simeunović, Valentina
Vukojević, Anđela
Todorović, Smilja
Mladenović, Aleksandra
Document Type:
Article (Published version)
,
© 2024 Elsevier B.V.
Metadata
Show full item recordAbstract:
Caloric restriction (CR) is known for its anti-aging benefits, partly due to reduced oxidative stress and enhanced antioxidant defense. However, CR outcomes vary based on its intensity, timing, and duration. This study explored CR's effects on antioxidant activity in the heart and liver of male Wistar rats during aging. We investigated two CR paradigms: long-term CR (LTCR), started early in life, and short-term CR (STCR), initiated in middle or old age for 3 months. Contrary to previous findings of short-term CR deleterious effects of on the nervous system, our results revealed increased levels of key antioxidants after STCR. More specifically, we found an increase in GSH-Px and GSH under STCR that was particularly pronounced in the liver, while an increase in CAT and GR activities was observed in the heart of the STCR groups. Catalase was characterized as an enzyme particularly responsive to CR, as its activity was also increased in both the liver and heart after long-term caloric restriction. Our results highlight a significant tissue-specific response to CR and contribute to our understanding of the dynamic effects of CR, which in turn has implications for refining its therapeutic potential in combating age-related decline.
Keywords:
Aging; Caloric restriction; Oxidative stress; Antioxidants; Heart; LiverSource:
Mechanisms of Ageing and Development, 2024, 222, 111992-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)