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Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic
dc.creator | Stančić, Ana | |
dc.creator | Otašević, Vesna | |
dc.creator | Janković, Aleksandra | |
dc.creator | Vučetić, Milica | |
dc.creator | Ivanović-Burmazović, Ivana S | |
dc.creator | Filipović, Milos R | |
dc.creator | Korac, Aleksandra B | |
dc.creator | Markelić, Milica B | |
dc.creator | Velicković, Ksenija D | |
dc.creator | Golić, Igor | |
dc.creator | Buzadžić, Biljana J. | |
dc.creator | Korać, Bato | |
dc.date.accessioned | 2017-11-23T11:11:38Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2013 | sr |
dc.identifier.issn | 0361-9230 | sr |
dc.identifier.other | Rad_konverzija_2955 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/960 | |
dc.description.abstract | Hippocampal structural changes associated with diabetes-related cognitive impairments are well described, but their molecular background remained vague. We examined whether/how diabetes alters molecular basis of energy metabolism in hippocampus readily after diabetes onset, with special emphasis on its redox-sensitivity. To induce diabetes, adult Mill Hill hybrid hooded rats received a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were further divided in two subgroups receiving (i) or not (ii) superoxide dismutase (SOD) mimic, [Mn(II)(pyane)Cl-2] for 7 days, i.p. Treatment of the diabetic animals started after blood glucose level >= 12 mM. Diabetes decreased protein levels of oxidative phosphorylation components: complex III and ATP synthase. In contrast, protein amounts of glyceraldehyde-3-phosphate dehydrogenase, pyruvate dehydrogenase, and hypoxia-inducible factor-1 alpha - the key regulator of energy metabolism in stress conditions, were higher in diabetic animals. Treatment with SOD mimic restored/increased the levels of oxidative phosphorylation components and returned hypoxia-inducible factor-1 alpha to control level, while diabetes-induced up-regulation of glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase, was additionally stimulated. To conclude, our results provide insight into the earliest molecular changes of energy-producing pathways in diabetes that may account for structural/functional disturbance of hippocampus, seen during disease progression. Also, data suggest [Mn(II)(pyane)Cl-2] as potential therapeutic agent in cutting-edge approaches to threat this widespread metabolic disorder. (C) 2013 Elsevier Inc. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia [173054, 173055] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Brain Research Bulletin | sr |
dc.title | Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Велицковић, Ксенија Д; Кораћ, Бато М.; Бузаджић, Биљана Ј.; Голић, Игор; Маркелић, Милица Б; Корац, Aлександра Б; Филиповић, Милос Р; Ивановић-Бурмазовић, Ивана С; Вучетић, Милица; Оташевић, Весна; Јанковић, Aлександра; Станчић, Aна; | |
dc.citation.issue | null | sr |
dc.citation.volume | 99 | sr |
dc.citation.spage | 153 | sr |
dc.citation.epage | 33 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_960 |
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