Приказ основних података о документу
Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis
dc.creator | Saksida, Tamara | |
dc.creator | Miljković, Đorđe | |
dc.creator | Timotijević, Gordana S | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Mijatović, Sanja | |
dc.creator | Fagone, Paolo | |
dc.creator | Mangano, Katia | |
dc.creator | Mammana, Santa | |
dc.creator | Farina, Claudio | |
dc.creator | Ascione, Ester | |
dc.creator | Maiello, Valentina | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.date.accessioned | 2017-11-23T11:11:38Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2013 | sr |
dc.identifier.issn | 0165-5728 | sr |
dc.identifier.other | Rad_konverzija_2960 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/965 | |
dc.description.abstract | Transferrin (Tf) has a major role in T cell activation and proliferation. Here, we investigated whether Tf exerts immunomodulatory effects on T cells and in development of T-cell driven experimental autoimmune encephalomyelitis (EAE). While treatment of concanavalin A-stimulated splenocytes with apotransferrin (ApoTf) did not affect release of IL-1 beta, TNF, INF-gamma, IL-17, IL-4, and IL-10, it markedly and dose-dependently down-regulated synthesis of IL-2 in these cells. ApoTf also inhibited IL-2 generation in purified CD3(+) T cells and the effect was accompanied with down-regulation of MAPK p44/42 and NF kappa B signaling. Despite impeded IL-2 release, proliferation of splenocytes was not inhibited by ApoTf. Importantly, ApoTf ameliorated EAE in mice and significantly reduced ex vivo IL-2 production in proteolipid protein-specific lymphocytes. Thus ApoTf may be a promising beneficial agent for multiple sclerosis. (C) 2013 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Serbian Ministry of Education, Science and Technological Development [173013, 173035]; MIUR (Ministry of Education, University, Research) [795] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | sr |
dc.title | Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Маиелло, Валентина; Мијатовић, Сања A.; Тимотијевић, Гордана С; Стојановић, Ивана Д; Фагоне, Паоло; Мангано, Катиа; Маммана, Санта; Фарина, Цлаудио; Aсционе, Естер; Ницолетти, Фердинандо; Стошић-Грујичић, Станислава Д.; Саксида, Тамара; Миљковић, Ђорђе М.; | |
dc.citation.issue | 1-2 | sr |
dc.citation.volume | 262 | sr |
dc.citation.spage | 63 | sr |
dc.citation.epage | 78 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_965 |
Документи
Датотеке | Величина | Формат | Преглед |
---|---|---|---|
Уз овај запис нема датотека. |